Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-RHH |
| Location | 1254..1773 | Replicon | plasmid pICDC-VUN128_01 |
| Accession | NZ_CP063422 | ||
| Organism | Vibrio cholerae strain VC_hf7 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | B8QIS2 |
| Locus tag | INP70_RS19020 | Protein ID | WP_012615283.1 |
| Coordinates | 1254..1538 (-) | Length | 95 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | R4V7Y7 |
| Locus tag | INP70_RS19025 | Protein ID | WP_012615282.1 |
| Coordinates | 1531..1773 (-) | Length | 81 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| INP70_RS19015 | 471..863 | + | 393 | WP_000884724.1 | hypothetical protein | - |
| INP70_RS19020 | 1254..1538 | - | 285 | WP_012615283.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| INP70_RS19025 | 1531..1773 | - | 243 | WP_012615282.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
| INP70_RS19030 | 1817..2011 | - | 195 | WP_169692641.1 | hypothetical protein | - |
| INP70_RS19035 | 2753..2986 | + | 234 | WP_193836722.1 | hypothetical protein | - |
| INP70_RS19040 | 2979..3878 | + | 900 | WP_102137300.1 | site-specific integrase | - |
| INP70_RS19045 | 3875..4666 | + | 792 | WP_102137301.1 | hypothetical protein | - |
| INP70_RS19050 | 4707..5606 | - | 900 | WP_193836720.1 | replication initiation protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..6617 | 6617 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 95 a.a. Molecular weight: 11204.63 Da Isoelectric Point: 5.5048
>T178192 WP_012615283.1 NZ_CP063422:c1538-1254 [Vibrio cholerae]
MYKLSQKAADDFGDIYEYTFLNFGAEQADNYTDEMEQCLQTLSEAPFIGRDCSELRSGVRRHDHQKHAIFYRVREFDIFV
IRILHQQMNPMLHL
MYKLSQKAADDFGDIYEYTFLNFGAEQADNYTDEMEQCLQTLSEAPFIGRDCSELRSGVRRHDHQKHAIFYRVREFDIFV
IRILHQQMNPMLHL
Download Length: 285 bp
>T178192 NZ_CP083877:2618375-2618482 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA
Antitoxin
Download Length: 81 a.a. Molecular weight: 8885.14 Da Isoelectric Point: 6.9516
>AT178192 WP_012615282.1 NZ_CP063422:c1773-1531 [Vibrio cholerae]
MARTTSVTIGESLDCFIERMIATGRYGSTSEVMRSALRLLEQQENQQDLLRKALDEGEASGECSLSLKEVAARRKAKLHV
MARTTSVTIGESLDCFIERMIATGRYGSTSEVMRSALRLLEQQENQQDLLRKALDEGEASGECSLSLKEVAARRKAKLHV
Download Length: 243 bp
>AT178192 NZ_CP083877:c2618328-2618262 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A658H481 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | R4V7Y7 |