178190

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /BrnT(toxin)
Location 232569..233067 Replicon chromosome
Accession NZ_CP063421
Organism Vibrio cholerae strain VC_hf7

Toxin (Protein)


Gene name - Uniprot ID Q9KMK7
Locus tag INP70_RS15190 Protein ID WP_000589156.1
Coordinates 232569..232835 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9KMK6
Locus tag INP70_RS15195 Protein ID WP_000643598.1
Coordinates 232822..233067 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
INP70_RS15135 228115..228510 + 396 WP_000870846.1 DUF3465 domain-containing protein -
INP70_RS15140 228663..229151 + 489 WP_000424237.1 hypothetical protein -
INP70_RS15145 229135..229257 + 123 WP_193836677.1 DUF3265 domain-containing protein -
INP70_RS15150 229285..229761 + 477 WP_001047180.1 GNAT family N-acetyltransferase -
INP70_RS15155 230065..230236 + 172 Protein_257 DUF645 family protein -
INP70_RS15160 230437..230733 + 297 WP_000617998.1 Dabb family protein -
INP70_RS15165 230911..231324 + 414 WP_000451552.1 GNAT family N-acetyltransferase -
INP70_RS15170 231401..231520 + 120 WP_001891295.1 hypothetical protein -
INP70_RS15175 231469..231750 + 282 WP_002023460.1 DUF1289 domain-containing protein -
INP70_RS15180 231916..232017 + 102 WP_193836679.1 acetyltransferase -
INP70_RS15185 232007..232393 + 387 WP_000703159.1 VOC family protein -
INP70_RS15190 232569..232835 + 267 WP_000589156.1 BrnT family toxin Toxin
INP70_RS15195 232822..233067 + 246 WP_000643598.1 hypothetical protein Antitoxin
INP70_RS15200 233192..233587 + 396 WP_000046948.1 hypothetical protein -
INP70_RS15205 233737..234123 + 387 WP_001015082.1 MmcQ/YjbR family DNA-binding protein -
INP70_RS15210 234308..234712 + 405 WP_001127262.1 VOC family protein -
INP70_RS15215 234881..235462 + 582 WP_000391145.1 HD domain-containing protein -
INP70_RS15220 235764..235892 + 129 WP_000947521.1 DUF645 family protein -
INP70_RS15225 235908..235946 + 39 WP_108244118.1 hypothetical protein -
INP70_RS15230 236235..236660 + 426 WP_001891302.1 hypothetical protein -
INP70_RS15235 237217..237684 + 468 WP_001289285.1 OsmC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island dfrA31 - 152411..247312 94901
- inside Integron - - 153082..246602 93520


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(6-81)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10092.34 Da        Isoelectric Point: 7.3171

>T178190 WP_000589156.1 NZ_CP063421:232569-232835 [Vibrio cholerae]
MIKFEFDENKSRSNLEKHGIDFHTAQGLWNDSDLIEIPANTSDEPRYLVVGLLNGKHWSGVITYRGTNIRIISVRRSRKA
EVSLYESA

Download         Length: 267 bp

>T178190 NZ_CP083877:2318232-2319554 [Escherichia coli]
ATGCCTAAACTTGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCACCGGAGTGGTTAGCAAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CTGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCCAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTGACGTTAATACCCGAAGA
CGAAACCGTAACGCATCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGACTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCGCTAGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCACAGGAGAAGACAGCACTG
CTCAGAATAGGCAATGACTGGTGCATTCCGAAAGGAATAACGCCGACGACGCACATCATTAAATTACCGATTGGCGAAAT
CAGGCAGCCCAATGCGACGCTCGATCTCAGCCAAAGCGTTGATAATGAGTATTACTGTCTGCTGCTGGCGAAAGAACTTG
GGTTGAATGTTCCGGACGCAGAAATCATTAAAGCGGGAAATGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATGCTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGTCAGACATTCGGTTTACCTTCATCGGTGAAATA
TGAATCAGATGGAGGCCCAGGCATCGCGCGGATCATGGCTTTTTTGATGGGGTCCAGCGAGGCGCTGAAAGATCGCTATG
ATTTTATGAAATTCCAGGTCTTCCAGTGGTTGATTGGCGCAACGGACGGTCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGACTCACGCCATTTTACGACATCATTTCAGCATTTCCGGTCCTTGGCGGTACGGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTTTGGCGACAGCAAAGGTGCTGAGATTCCCGGAAGTGCAGATGCATGAAATCCTGAGTGACTTTGCCAGAATGATTCCA
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAAGCAATGTGTT
GAGGTTGCATGGACGGTTAAGCCGAGAATACGGTAGTAAGTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9478.77 Da        Isoelectric Point: 6.4832

>AT178190 WP_000643598.1 NZ_CP063421:232822-233067 [Vibrio cholerae]
MKAHEFDAKFESDDDDIVMDLDLSQAKRPMHKQKRVNVDFPAWMLESLDREASRIGVTRQSIIKIWLAERLESVSHHSSV
R

Download         Length: 246 bp

>AT178190 NZ_CP083877:2317966-2318232 [Escherichia coli]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTGGCGAATGCAATGAAACTGGTTCGCCAGCAAAATGGCTGGAC
GCAGAGCGAGCTGGCGAAAAAAATTGGTATTAAGCAGGCGACGATTTCCAATTTCGAAAACAACCCTGACAATACCACGC
TCACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACGCTATGCGACGCGAAAAATGCCTCGCCAGAATCA
ACAGAACAGCAAAATCTGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A271VMP7

Antitoxin

Source ID Structure
AlphaFold DB A0A271VME2

References