Detailed information of TA system TA178189

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-Phd
• Location: 226112..226690
• Replicon: chromosome
• Accession: NZ_CP063421
• Organism: Vibrio cholerae strain VC_hf7

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: INP70_RS15115
• Protein ID: WP_001180240.1
• Coordinates: 226112..226429 (-)
• Length: 106 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q7DCR7
• Locus tag: INP70_RS15120
• Protein ID: WP_000557292.1
• Coordinates: 226448..226690 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
INP70_RS15080	221490..222494	+	1005	WP_000964930.1	LD-carboxypeptidase	-
INP70_RS15085	222611..222910	-	300	WP_000802134.1	type II toxin-antitoxin system RelE/ParE family toxin	-
INP70_RS15090	222907..223149	-	243	WP_001107720.1	type II toxin-antitoxin system ParD family antitoxin	-
INP70_RS15095	223944..224375	+	432	WP_000795498.1	hypothetical protein	-
INP70_RS15100	224520..225034	+	515	Protein_246	GNAT family N-acetyltransferase	-
INP70_RS15105	225035..225151	+	117	WP_072612049.1	DUF3265 domain-containing protein	-
INP70_RS15110	225193..225969	+	777	WP_000758202.1	hypothetical protein	-
INP70_RS15115	226112..226429	-	318	WP_001180240.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
INP70_RS15120	226448..226690	-	243	WP_000557292.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
INP70_RS15125	227082..227261	+	180	WP_032476891.1	DUF645 family protein	-
INP70_RS15130	227538..227828	+	291	WP_148529225.1	DUF3709 domain-containing protein	-
INP70_RS15135	228115..228510	+	396	WP_000870846.1	DUF3465 domain-containing protein	-
INP70_RS15140	228663..229151	+	489	WP_000424237.1	hypothetical protein	-
INP70_RS15145	229135..229257	+	123	WP_193836677.1	DUF3265 domain-containing protein	-
INP70_RS15150	229285..229761	+	477	WP_001047180.1	GNAT family N-acetyltransferase	-
INP70_RS15155	230065..230236	+	172	Protein_257	DUF645 family protein	-
INP70_RS15160	230437..230733	+	297	WP_000617998.1	Dabb family protein	-
INP70_RS15165	230911..231324	+	414	WP_000451552.1	GNAT family N-acetyltransferase	-
INP70_RS15170	231401..231520	+	120	WP_001891295.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	dfrA31	-	152411..247312	94901
	-	inside	Integron	-	-	153082..246602	93520

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-93)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-71)

Sequences

Toxin

Protein

• Length: 106 a.a.
• Molecular weight: 12115.92 Da
• Isoelectric Point: 9.3000

>T178189 WP_001180240.1 NZ_CP063421:c226429-226112 [Vibrio cholerae]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAD
CILIVAVLGQSQLPQKHLKQSRFVS

Nucleotide

• Length: 318 bp

>T178189 NZ_CP083877:2007592-2007695 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8961.25 Da
• Isoelectric Point: 5.6630

>AT178189 WP_000557292.1 NZ_CP063421:c226690-226448 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Nucleotide

• Length: 243 bp

>AT178189 NZ_CP083877:c2007733-2007462 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Structures

Antitoxin

• AlphaFold DB: Q7DCR7