Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-RHH |
| Location | 191653..192191 | Replicon | chromosome |
| Accession | NZ_CP063421 | ||
| Organism | Vibrio cholerae strain VC_hf7 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | - |
| Locus tag | INP70_RS14855 | Protein ID | WP_000802134.1 |
| Coordinates | 191653..191952 (-) | Length | 100 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | A0A271VK51 |
| Locus tag | INP70_RS14860 | Protein ID | WP_001107720.1 |
| Coordinates | 191949..192191 (-) | Length | 81 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| INP70_RS14800 | 187102..187488 | + | 387 | WP_001015082.1 | MmcQ/YjbR family DNA-binding protein | - |
| INP70_RS14805 | 187665..187931 | + | 267 | WP_000589156.1 | BrnT family toxin | - |
| INP70_RS14810 | 187918..188163 | + | 246 | WP_000643598.1 | hypothetical protein | - |
| INP70_RS14815 | 188304..188729 | + | 426 | WP_002023452.1 | GNAT family N-acetyltransferase | - |
| INP70_RS14820 | 188848..189129 | + | 282 | WP_002023460.1 | DUF1289 domain-containing protein | - |
| INP70_RS14825 | 189542..189713 | + | 172 | Protein_191 | DUF645 family protein | - |
| INP70_RS14830 | 189913..190191 | - | 279 | WP_000578475.1 | type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family | - |
| INP70_RS14835 | 190188..190472 | - | 285 | WP_000381184.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | - |
| INP70_RS14840 | 190826..190954 | + | 129 | WP_000947521.1 | DUF645 family protein | - |
| INP70_RS14845 | 190970..191008 | + | 39 | WP_108244118.1 | hypothetical protein | - |
| INP70_RS14850 | 191214..191525 | + | 312 | WP_000623749.1 | hypothetical protein | - |
| INP70_RS14855 | 191653..191952 | - | 300 | WP_000802134.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| INP70_RS14860 | 191949..192191 | - | 243 | WP_001107720.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
| INP70_RS14865 | 192991..193971 | + | 981 | WP_000738239.1 | DUF3883 domain-containing protein | - |
| INP70_RS14870 | 194185..194475 | + | 291 | WP_148529225.1 | DUF3709 domain-containing protein | - |
| INP70_RS14875 | 194837..195262 | + | 426 | WP_002023413.1 | hypothetical protein | - |
| INP70_RS14880 | 195415..196095 | + | 681 | WP_000164130.1 | hypothetical protein | - |
| INP70_RS14885 | 196257..196895 | + | 639 | WP_000230121.1 | HD domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | dfrA31 | - | 152411..247312 | 94901 | |
| - | inside | Integron | - | - | 153082..246602 | 93520 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 100 a.a. Molecular weight: 11601.34 Da Isoelectric Point: 9.9232
>T178186 WP_000802134.1 NZ_CP063421:c191952-191653 [Vibrio cholerae]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQIGSQQ
IRVIRILHKSMDVNPIFGA
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQIGSQQ
IRVIRILHKSMDVNPIFGA
Download Length: 300 bp
>T178186 NZ_CP083877:998527-998862 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG
Antitoxin
Download Length: 81 a.a. Molecular weight: 8950.82 Da Isoelectric Point: 4.1677
>AT178186 WP_001107720.1 NZ_CP063421:c192191-191949 [Vibrio cholerae]
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLVEGEQSGDADYDLDSFINELDSENIR
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLVEGEQSGDADYDLDSFINELDSENIR
Download Length: 243 bp
>AT178186 NZ_CP083877:998279-998527 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|