Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /BrnT(toxin) |
| Location | 165249..165747 | Replicon | chromosome |
| Accession | NZ_CP063421 | ||
| Organism | Vibrio cholerae strain VC_hf7 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | Q9KMK7 |
| Locus tag | INP70_RS14610 | Protein ID | WP_000589156.1 |
| Coordinates | 165249..165515 (+) | Length | 89 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | Q9KMK6 |
| Locus tag | INP70_RS14615 | Protein ID | WP_000643598.1 |
| Coordinates | 165502..165747 (+) | Length | 82 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| INP70_RS14565 | 160474..160599 | + | 126 | WP_002023455.1 | DUF645 family protein | - |
| INP70_RS14570 | 160603..160656 | + | 54 | Protein_140 | DUF645 family protein | - |
| INP70_RS14575 | 160873..161607 | + | 735 | WP_000653371.1 | hypothetical protein | - |
| INP70_RS14580 | 161749..162237 | + | 489 | WP_000424237.1 | hypothetical protein | - |
| INP70_RS14585 | 162371..162796 | + | 426 | WP_000403002.1 | GNAT family N-acetyltransferase | - |
| INP70_RS14590 | 163001..163390 | + | 390 | WP_000491267.1 | VOC family protein | - |
| INP70_RS14595 | 163871..163981 | + | 111 | WP_089072380.1 | DUF3265 domain-containing protein | - |
| INP70_RS14600 | 164214..164321 | + | 108 | WP_088132626.1 | DUF645 family protein | - |
| INP70_RS14605 | 164544..165059 | + | 516 | WP_000100088.1 | ClbS/DfsB family four-helix bundle protein | - |
| INP70_RS14610 | 165249..165515 | + | 267 | WP_000589156.1 | BrnT family toxin | Toxin |
| INP70_RS14615 | 165502..165747 | + | 246 | WP_000643598.1 | hypothetical protein | Antitoxin |
| INP70_RS14620 | 165888..166424 | + | 537 | WP_172790006.1 | nucleotidyltransferase family protein | - |
| INP70_RS14625 | 166481..166573 | + | 93 | WP_192858804.1 | acetyltransferase | - |
| INP70_RS14630 | 166561..167487 | + | 927 | WP_000377813.1 | hypothetical protein | - |
| INP70_RS14635 | 167625..168572 | + | 948 | WP_000688114.1 | phospholipase D family protein | - |
| INP70_RS14640 | 168726..169151 | + | 426 | WP_001287987.1 | bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD | - |
| INP70_RS14645 | 169457..169639 | + | 183 | WP_000947620.1 | DUF645 family protein | - |
| INP70_RS14650 | 169924..170202 | + | 279 | WP_000280315.1 | DUF3709 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | dfrA31 | - | 152411..247312 | 94901 | |
| - | inside | Integron | - | - | 153082..246602 | 93520 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10092.34 Da Isoelectric Point: 7.3171
>T178181 WP_000589156.1 NZ_CP063421:165249-165515 [Vibrio cholerae]
MIKFEFDENKSRSNLEKHGIDFHTAQGLWNDSDLIEIPANTSDEPRYLVVGLLNGKHWSGVITYRGTNIRIISVRRSRKA
EVSLYESA
MIKFEFDENKSRSNLEKHGIDFHTAQGLWNDSDLIEIPANTSDEPRYLVVGLLNGKHWSGVITYRGTNIRIISVRRSRKA
EVSLYESA
Download Length: 267 bp
>T178181 NZ_CP083877:c52228-51851 [Escherichia coli]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCATTACGGCCTTACGCTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGGCCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCATTACGGCCTTACGCTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGGCCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA
Antitoxin
Download Length: 82 a.a. Molecular weight: 9478.77 Da Isoelectric Point: 6.4832
>AT178181 WP_000643598.1 NZ_CP063421:165502-165747 [Vibrio cholerae]
MKAHEFDAKFESDDDDIVMDLDLSQAKRPMHKQKRVNVDFPAWMLESLDREASRIGVTRQSIIKIWLAERLESVSHHSSV
R
MKAHEFDAKFESDDDDIVMDLDLSQAKRPMHKQKRVNVDFPAWMLESLDREASRIGVTRQSIIKIWLAERLESVSHHSSV
R
Download Length: 246 bp
>AT178181 NZ_CP083877:c52686-52318 [Escherichia coli]
GTGTCAGACACATTCTCCGGGACAACGCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGTACCGTGAC
ACCTTGTTTTGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCGGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCTAAAGGGCTGACCTGCGATGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACCCCCGAAACGAAAAAGTAA
GTGTCAGACACATTCTCCGGGACAACGCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGTACCGTGAC
ACCTTGTTTTGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCGGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCTAAAGGGCTGACCTGCGATGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACCCCCGAAACGAAAAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A271VMP7 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A271VME2 |