Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 2164063..2165888 Replicon chromosome
Accession NZ_CP063420
Organism Vibrio cholerae strain VC_hf7

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag INP70_RS09760 Protein ID WP_000391997.1
Coordinates 2164063..2165424 (+) Length 454 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag INP70_RS09765 Protein ID WP_000804846.1
Coordinates 2165421..2165888 (+) Length 156 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
INP70_RS09730 2159598..2161262 + 1665 WP_000879550.1 DNA repair protein RecN -
INP70_RS09735 2161421..2161780 + 360 WP_001160914.1 outer membrane protein assembly factor BamE -
INP70_RS09740 2161856..2162161 - 306 WP_001918351.1 RnfH family protein -
INP70_RS09745 2162164..2162598 - 435 WP_000815880.1 type II toxin-antitoxin system RatA family toxin -
INP70_RS09750 2162782..2163267 + 486 WP_000162689.1 SsrA-binding protein SmpB -
INP70_RS09760 2164063..2165424 + 1362 WP_000391997.1 type II toxin-antitoxin system HipA family toxin Toxin
INP70_RS09765 2165421..2165888 + 468 WP_000804846.1 helix-turn-helix domain-containing protein Antitoxin
INP70_RS09770 2166316..2166894 + 579 WP_000109982.1 class I SAM-dependent methyltransferase -
INP70_RS09775 2166898..2169834 + 2937 WP_001283874.1 DEAD/DEAH box helicase family protein -
INP70_RS09780 2169904..2170854 + 951 WP_000635667.1 NERD domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(166-383)

Antitoxin

Cro/C1-type helix-turn-helix domain

(80-138)


Sequences

Toxin        


Download         Length: 454 a.a.        Molecular weight: 51307.21 Da        Isoelectric Point: 4.9109

>T178180 WP_000391997.1 NZ_CP063420:2164063-2165424 [Vibrio cholerae]
MEELTVQAFIRGEWIDIGIISFPKSSQHNFRVTELNYLSDYALEHYDKDDFHAVSLNHPVSFFFDDMGKPGWLKFLDDIM
PSGASRRYWVKHLDIEDLSSDEQDYVLLKFGTMSPIGNLRIKDSLPERYEVADNLYFSVDDVKNRAGDFLDYAQQRGAAA
GGATGAGGEAPKLILRCGFDHGSGSEKIWIDPYQDDNSNHDLHYLVKYPRGSRSTIDCNILRAEFYFYHELTEMGVETIS
TDGMRLEEGLNYPSLWLPRFDVQIIDQQIERFGMESVYSILNKGAGVTLDHETTIRTLIEKITESNMVKHQGYRFDTQAF
VIEWVKRDLLNILFGNSDNHGRNTSFLKGDGVIKLAPIYDFAPMKADPAGIPRTTKWKAPLEVGGTYDFVGIADTLSDLV
PKEMLLKELAITASKCVGLKQRLALRGVPEQILEMPAVGLNYLSEKLTKWGLL

Download         Length: 1362 bp

>T178180 NZ_CP063420:2164063-2165424 [Vibrio cholerae]
ATGGAAGAGCTAACCGTACAAGCTTTTATCAGAGGTGAATGGATAGATATTGGTATCATCTCATTCCCTAAAAGTAGCCA
ACATAATTTTCGAGTGACTGAACTCAACTATCTCAGCGACTATGCGCTAGAACATTACGATAAAGATGACTTTCACGCTG
TTTCACTAAACCACCCAGTCTCATTCTTTTTTGATGACATGGGTAAGCCTGGATGGTTAAAGTTTCTAGACGATATTATG
CCTAGTGGCGCTAGTAGACGATACTGGGTCAAACACCTAGATATTGAAGATCTTAGTTCTGATGAACAAGACTATGTTTT
GCTCAAATTTGGCACGATGTCGCCTATTGGTAACTTAAGAATAAAAGACTCCCTTCCTGAACGCTACGAAGTCGCAGACA
ACCTCTACTTCTCTGTTGATGATGTTAAAAATCGAGCTGGTGATTTCCTCGACTACGCACAGCAAAGAGGGGCAGCCGCA
GGTGGTGCAACTGGGGCTGGAGGTGAAGCGCCAAAACTGATCCTCCGATGTGGTTTCGATCATGGATCTGGCAGCGAAAA
AATATGGATTGATCCATACCAAGATGACAATAGCAACCACGACTTACATTACTTAGTAAAGTACCCTAGAGGCTCAAGAA
GCACCATCGACTGTAATATTCTAAGAGCTGAGTTCTACTTCTACCACGAGCTAACTGAAATGGGAGTTGAAACGATCTCC
ACCGACGGTATGCGCTTGGAGGAAGGATTAAACTACCCTTCCTTATGGCTTCCTCGATTTGATGTTCAAATTATTGATCA
ACAAATAGAGCGATTTGGCATGGAATCAGTGTATTCCATTTTGAACAAAGGCGCTGGAGTCACTCTTGATCACGAAACAA
CAATCCGAACTCTCATAGAAAAAATTACTGAAAGTAATATGGTTAAACACCAAGGGTATAGGTTTGATACCCAAGCTTTC
GTTATTGAATGGGTGAAGAGAGATCTACTCAACATCTTGTTTGGTAATAGTGATAACCATGGCAGAAATACTTCATTCTT
AAAGGGCGATGGAGTCATAAAGCTTGCTCCCATTTACGATTTCGCACCAATGAAAGCAGATCCTGCAGGAATTCCAAGAA
CAACAAAATGGAAAGCCCCACTAGAGGTTGGCGGAACTTACGACTTTGTCGGCATTGCAGACACCTTATCTGATCTGGTA
CCAAAGGAAATGTTATTAAAAGAGCTAGCAATTACTGCAAGTAAATGCGTAGGCCTAAAGCAGAGACTCGCTTTACGAGG
AGTACCAGAACAAATCTTGGAGATGCCGGCCGTTGGACTTAATTATTTATCAGAAAAGCTCACTAAATGGGGGCTACTAT
GA

Antitoxin


Download         Length: 156 a.a.        Molecular weight: 17047.52 Da        Isoelectric Point: 10.7084

>AT178180 WP_000804846.1 NZ_CP063420:2165421-2165888 [Vibrio cholerae]
MKPSNKESVQDTVARLRANRNQQQPKVGKNATHSSKEQTPLDTPTRSKASKNAKAVSAAERKTEANKIIKHLLLGELTQG
QALKSLRINILGLKQDVFARLVDVSRKTLSDIENDRGSYNTEILNKVFKPFSLKIGLLPSSPDALKSLLMDGEDG

Download         Length: 468 bp

>AT178180 NZ_CP063420:2165421-2165888 [Vibrio cholerae]
ATGAAGCCAAGCAATAAAGAGTCCGTACAAGATACGGTAGCTCGTCTAAGAGCAAACCGAAATCAACAGCAGCCCAAGGT
TGGGAAGAATGCAACTCATTCGAGCAAAGAGCAAACACCACTCGATACTCCAACGAGATCGAAAGCCTCAAAAAACGCCA
AAGCAGTAAGTGCAGCAGAGCGCAAAACCGAGGCAAACAAAATCATCAAACACTTATTGCTTGGAGAGCTAACACAGGGC
CAAGCGCTGAAAAGTCTACGCATTAATATACTGGGACTCAAACAGGATGTATTCGCAAGACTTGTCGATGTCTCAAGAAA
AACACTCTCAGACATAGAGAATGATCGGGGCAGCTACAATACAGAGATTCTCAACAAGGTATTCAAACCATTTAGCTTAA
AAATCGGGCTGCTGCCTTCTTCTCCCGATGCGTTAAAATCGCTCTTAATGGATGGTGAGGATGGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References