Detailed information of TA system TA178179

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): CapRel-ATcapRel/-
• Location: 1873109..1874136
• Replicon: chromosome
• Accession: NZ_CP063418
• Organism: Actinomyces sp. ZJ34

Toxin (Protein)

• Gene name: capRel
• Uniprot ID: -
• Locus tag: HRL51_RS08080
• Protein ID: WP_172191196.1
• Coordinates: 1873109..1873855 (+)
• Length: 249 a.a.

Antitoxin (Protein)

• Gene name: ATcapRel
• Uniprot ID: -
• Locus tag: HRL51_RS08085
• Protein ID: WP_172120204.1
• Coordinates: 1873852..1874136 (+)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HRL51_RS08035	1869169..1869459	-	291	WP_172191186.1	FMN-dependent dehydrogenase	-
HRL51_RS08045	1870703..1871017	+	315	WP_172191188.1	tyrosine-type recombinase/integrase	-
HRL51_RS08050	1871173..1871628	+	456	WP_172191946.1	DUF4065 domain-containing protein	-
HRL51_RS08055	1871696..1871839	+	144	WP_172120990.1	hypothetical protein	-
HRL51_RS08060	1871898..1872272	-	375	WP_172191190.1	helix-turn-helix transcriptional regulator	-
HRL51_RS08065	1872275..1872474	-	200	Protein_1561	hypothetical protein	-
HRL51_RS08070	1872564..1872764	-	201	WP_172191192.1	hypothetical protein	-
HRL51_RS08075	1872780..1873007	-	228	WP_172191194.1	hypothetical protein	-
HRL51_RS08080	1873109..1873855	+	747	WP_172191196.1	RelA/SpoT domain-containing protein	Toxin
HRL51_RS08085	1873852..1874136	+	285	WP_172120204.1	hypothetical protein	Antitoxin
HRL51_RS08090	1874300..1874614	+	315	WP_172191198.1	hypothetical protein	-
HRL51_RS08095	1874892..1875083	+	192	WP_172191200.1	hypothetical protein	-
HRL51_RS08100	1875357..1875485	-	129	WP_172120207.1	LPXTG cell wall anchor domain-containing protein	-
HRL51_RS08105	1875577..1875975	+	399	WP_172191202.1	hypothetical protein	-
HRL51_RS08110	1875941..1876723	-	783	WP_172191204.1	MBL fold metallo-hydrolase	-
HRL51_RS08115	1876747..1877718	-	972	WP_172191948.1	nitronate monooxygenase	-
HRL51_RS08125	1878638..1878802	-	165	WP_006548624.1	50S ribosomal protein L32	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RelA/SpoT (74-176)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 249 a.a.
• Molecular weight: 28054.93 Da
• Isoelectric Point: 8.9730

>T178179 WP_172191196.1 NZ_CP063418:1873109-1873855 [Actinomyces sp. ZJ34]
VSTWDLPSPSRINKAGRRVRRWLEGQELDQSTIQADLDVIDVFRASHQKPMNAASTGLRSIVRTVDCRSPEVSQRLKRWG
SLTSKLLTQPTLALSRMQDLAGCRAVLDDMDEIYRVRKRLEKNRPVLDVSDYITHPKPSGYRGVHVVVEYGSADGNYPAR
PVEIQLRTRVMHQWAISIEDMNARLTEQFRTHEFDLKRGIGPAEVLDVFSVTSEVMAAAENHQAPPADMIGRLEAAQKAF
TEYLRGMS

Nucleotide

• Length: 747 bp

>T178179 NZ_CP083875:c146498-146193 [Escherichia coli]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTACAGAGTGATATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCACGTCTGCTGTCAGATAAAGTCTCCCGTGAACTTTACCCGGTGG
TGCATATCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGCCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10488.69 Da
• Isoelectric Point: 4.6389

>AT178179 WP_172120204.1 NZ_CP063418:1873852-1874136 [Actinomyces sp. ZJ34]
MTSGSNLVHFILVYDHRRGDLREEIPFGSNSKAAVEAYTSLERQYKDDKGIEIVLVGADSFDTIRQTHANYFADSREDLI
TEPLLKGLLDAVGS

Nucleotide

• Length: 285 bp

>AT178179 NZ_CP083875:c146718-146500 [Escherichia coli]
ATGAAGCAGCGTATTACAGTGACAGTTGACAGCGACAGCTATCAGTTGCTCAAGGCATATGATGTCAATATCTCCGGTCT
GGTAAGCACAACCATGCAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGAAAGCGGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCTGACGAGAACAGGGACTGGTGA