Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 757778..758337 Replicon chromosome
Accession NZ_CP063418
Organism Actinomyces sp. ZJ34

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag HRL51_RS03060 Protein ID WP_172119570.1
Coordinates 757778..758074 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag HRL51_RS03065 Protein ID WP_172193329.1
Coordinates 758074..758337 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HRL51_RS03035 753270..755027 - 1758 WP_172193321.1 relaxase/mobilization nuclease domain-containing protein -
HRL51_RS03040 755024..755455 - 432 WP_172193323.1 plasmid mobilization relaxosome protein MobC -
HRL51_RS03045 755973..756236 + 264 WP_172193325.1 hypothetical protein -
HRL51_RS03050 756323..756730 + 408 WP_172193327.1 DNA-processing protein DprA -
HRL51_RS03055 756699..757478 + 780 WP_172119571.1 DUF3800 domain-containing protein -
HRL51_RS03060 757778..758074 - 297 WP_172119570.1 type II toxin-antitoxin system YafQ family toxin Toxin
HRL51_RS03065 758074..758337 - 264 WP_172193329.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HRL51_RS03070 758469..759512 - 1044 WP_172193386.1 lytic transglycosylase domain-containing protein -
HRL51_RS03075 759548..759916 - 369 WP_172193331.1 hypothetical protein -
HRL51_RS03080 760109..760336 + 228 WP_172193333.1 ribbon-helix-helix protein, CopG family -
HRL51_RS03085 760320..760577 + 258 WP_172193334.1 type II toxin-antitoxin system RelE/ParE family toxin -
HRL51_RS03090 760698..760907 - 210 WP_172193336.1 hypothetical protein -
HRL51_RS03095 762212..763039 - 828 WP_172193338.1 tyrosine-type recombinase/integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(9-96)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-78)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11249.77 Da        Isoelectric Point: 7.1297

>T178176 WP_172119570.1 NZ_CP063418:c758074-757778 [Actinomyces sp. ZJ34]
MVLAPEPTPRFRRDVKALRKKHVDLAPLREVIDLIVADTDQARDELVRHHGMHRLRGQWEASNECHVANAGDWLLIWTTT
QTQAILQRTGGHDDLFGH

Download         Length: 297 bp

>T178176 NZ_CP083872:c4124474-4124124 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GTGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTT
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9779.95 Da        Isoelectric Point: 4.3988

>AT178176 WP_172193329.1 NZ_CP063418:c758337-758074 [Actinomyces sp. ZJ34]
MATITVRVEDSVKEGVTQIAEDFGFDLSSVTRAFYLQMIREHRIPLNLSYPQPSAASREAIEQTRQIIASGQHTYDTAEA
MYEDLGL

Download         Length: 264 bp

>AT178176 NZ_CP083872:c4124719-4124468 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAAGCGCAGGTGAGCAACAACCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References