Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/MazF(toxin)
Location 270247..270883 Replicon chromosome
Accession NZ_CP063414
Organism Parageobacillus thermoglucosidasius strain 23.6

Toxin (Protein)


Gene name mazF Uniprot ID L7ZVP1
Locus tag IMI45_RS01255 Protein ID WP_003253417.1
Coordinates 270533..270883 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A178U3Z0
Locus tag IMI45_RS01250 Protein ID WP_003253419.1
Coordinates 270247..270528 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IMI45_RS01230 (IMI45_01220) 266654..267268 - 615 WP_013401779.1 rhomboid family intramembrane serine protease -
IMI45_RS01235 (IMI45_01225) 267331..267693 + 363 WP_003253427.1 holo-ACP synthase -
IMI45_RS01240 (IMI45_01230) 267775..268788 + 1014 WP_256833869.1 outer membrane lipoprotein carrier protein LolA -
IMI45_RS01245 (IMI45_01235) 268970..270124 + 1155 WP_256833873.1 alanine racemase -
IMI45_RS01250 (IMI45_01240) 270247..270528 + 282 WP_003253419.1 hypothetical protein Antitoxin
IMI45_RS01255 (IMI45_01245) 270533..270883 + 351 WP_003253417.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
IMI45_RS01260 (IMI45_01250) 271102..273288 + 2187 WP_125010675.1 Tex family protein -
IMI45_RS01265 (IMI45_01255) 273283..273396 - 114 WP_013401775.1 cortex morphogenetic protein CmpA -
IMI45_RS01270 (IMI45_01260) 273484..273951 + 468 WP_256833880.1 SprT family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12992.00 Da        Isoelectric Point: 4.8781

>T178175 WP_003253417.1 NZ_CP063414:270533-270883 [Parageobacillus thermoglucosidasius]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLGLIDF

Download         Length: 351 bp

>T178175 NZ_CP083872:c4013980-4013693 [Escherichia coli]
ATGCCAATGGAGTTTGAATGGGATGAAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTATTGTTTGATGATCCACAACATTTGTCACAGCAAGAACGCATAGAAAACGGTGAGTATCGCTGGCAGACAATCGGCC
TGGTTTACGGCATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAATCGCTATGAGCATGGTTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10631.16 Da        Isoelectric Point: 7.0142

>AT178175 WP_003253419.1 NZ_CP063414:270247-270528 [Parageobacillus thermoglucosidasius]
VSESSATTEIVVRLPQALVTELDVLVKQENGNRNDLIYQATKMYIRERKKRQIREAMRRGYMEMAKINLSIASEAFLAEY
EADHTVERLVSGG

Download         Length: 282 bp

>AT178175 NZ_CP083872:c4013706-4013404 [Escherichia coli]
ATGAGCATGGTTAAACATAAACGAGGGACCTCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGCGCTGACGAA
TAAATCCGACGAAGATATTGATTACAGTGATATCCCACCTTCCAGCGATGAGCAATGGTCTAACGCCGAACGCGGTAAGT
TTTATCGGCCATTGAAAACTCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGTTGAAGCGACCAGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9ERQ4

Antitoxin

Source ID Structure
AlphaFold DB A0A178U3Z0

References