Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2662227..2663815 Replicon chromosome
Accession NZ_CP063403
Organism Klebsiella variicola strain 8917

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag AMN10_RS13170 Protein ID WP_044650455.1
Coordinates 2662227..2663549 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag AMN10_RS13175 Protein ID WP_072045542.1
Coordinates 2663549..2663815 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AMN10_RS13145 2657379..2657585 + 207 WP_004205917.1 helix-turn-helix transcriptional regulator -
AMN10_RS13150 2657745..2658032 - 288 WP_008804913.1 type 1 fimbrial protein -
AMN10_RS13155 2658075..2659793 + 1719 Protein_2586 fimbrial biogenesis outer membrane usher protein -
AMN10_RS13160 2659781..2660785 + 1005 WP_039103406.1 type 1 fimbrial protein -
AMN10_RS13165 2660918..2662210 + 1293 WP_012968243.1 glycoside hydrolase family 10 protein -
AMN10_RS13170 2662227..2663549 - 1323 WP_044650455.1 type II toxin-antitoxin system HipA family toxin Toxin
AMN10_RS13175 2663549..2663815 - 267 WP_072045542.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
AMN10_RS13180 2664081..2664407 - 327 WP_072045543.1 hydroxyisourate hydrolase -
AMN10_RS13185 2664404..2664904 - 501 WP_008804922.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
AMN10_RS13190 2664882..2666261 - 1380 Protein_2593 purine permease -
AMN10_RS13195 2666607..2667761 + 1155 WP_023322603.1 FAD-dependent urate hydroxylase HpxO -
AMN10_RS13200 2667742..2668665 - 924 WP_008804925.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 48941.29 Da        Isoelectric Point: 7.5644

>T178171 WP_044650455.1 NZ_CP063403:c2663549-2662227 [Klebsiella variicola]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGGHWCIPQGTTPTTHIIKLPIGEIKQPNATLDLRESVDNEFLCLALARELGLAVPEAEIITTPWIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGIPSSMKYESDGGPGIAAIMAFLLGSSEALKDRADFMKFMVFQWLVGATDGHAKNFSLFLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPGEQMLAILQEFAGHVP
QAIESARRTLPADFSTHVWRAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

>T178171 NZ_CP083872:2591515-2591622 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9851.23 Da        Isoelectric Point: 9.7364

>AT178171 WP_072045542.1 NZ_CP063403:c2663815-2663549 [Klebsiella variicola]
MTSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKATGTAPAP
DNNTDLDW

Download         Length: 267 bp

>AT178171 NZ_CP083872:c2591468-2591402 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References