Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 774912..775569 Replicon chromosome
Accession NZ_CP063403
Organism Klebsiella variicola strain 8917

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag AMN10_RS03825 Protein ID WP_002916310.1
Coordinates 775159..775569 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag AMN10_RS03820 Protein ID WP_002916312.1
Coordinates 774912..775178 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AMN10_RS03795 769957..771390 - 1434 WP_072046106.1 6-phospho-beta-glucosidase BglA -
AMN10_RS03800 771510..772238 - 729 WP_012967245.1 MurR/RpiR family transcriptional regulator -
AMN10_RS03805 772289..772600 + 312 WP_060619869.1 N(4)-acetylcytidine aminohydrolase -
AMN10_RS03810 772764..773423 + 660 WP_008806429.1 hemolysin III family protein -
AMN10_RS03815 773683..774666 - 984 WP_012967246.1 tRNA-modifying protein YgfZ -
AMN10_RS03820 774912..775178 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
AMN10_RS03825 775159..775569 + 411 WP_002916310.1 protein YgfX Toxin
AMN10_RS03830 775576..776097 - 522 WP_008806427.1 flavodoxin FldB -
AMN10_RS03835 776198..777094 + 897 WP_008806426.1 site-specific tyrosine recombinase XerD -
AMN10_RS03840 777117..777830 + 714 WP_008806425.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
AMN10_RS03845 777836..779569 + 1734 WP_008806424.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T178161 WP_002916310.1 NZ_CP063403:775159-775569 [Klebsiella variicola]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T178161 NZ_CP083872:c620155-619691 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAGACAGAAGAACCCCATTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT178161 WP_002916312.1 NZ_CP063403:774912-775178 [Klebsiella variicola]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT178161 NZ_CP083872:c620490-620155 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References