Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 319167..319753 Replicon chromosome
Accession NZ_CP063403
Organism Klebsiella variicola strain 8917

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag AMN10_RS01460 Protein ID WP_012967118.1
Coordinates 319385..319753 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A1F2M0C2
Locus tag AMN10_RS01455 Protein ID WP_032731361.1
Coordinates 319167..319388 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AMN10_RS01435 315324..316250 + 927 WP_012540389.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
AMN10_RS01440 316247..317524 + 1278 WP_008806971.1 branched chain amino acid ABC transporter permease LivM -
AMN10_RS01445 317521..318288 + 768 WP_008806972.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
AMN10_RS01450 318290..319003 + 714 WP_004145133.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF -
AMN10_RS01455 319167..319388 + 222 WP_032731361.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
AMN10_RS01460 319385..319753 + 369 WP_012967118.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
AMN10_RS01465 320045..321361 + 1317 WP_008806974.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
AMN10_RS01470 321468..322355 + 888 WP_012967120.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -
AMN10_RS01475 322352..323197 + 846 WP_044643074.1 sn-glycerol-3-phosphate ABC transporter permease UgpE -
AMN10_RS01480 323199..324269 + 1071 WP_072045659.1 sn-glycerol-3-phosphate import ATP-binding protein UgpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 316247..325006 8759


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(26-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-50)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13584.98 Da        Isoelectric Point: 8.6410

>T178160 WP_012967118.1 NZ_CP063403:319385-319753 [Klebsiella variicola]
MTLQIISAEEIIQFHDRLLRVTPGVAGMPDPGRAEAIMYRVLNKIEYEGMTDVWRLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGIILPANPDFVGMTVEAAAGQLTLEQIVARLRG

Download         Length: 369 bp

>T178160 NZ_CP083872:202811-202918 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8165.18 Da        Isoelectric Point: 4.7769

>AT178160 WP_032731361.1 NZ_CP063403:319167-319388 [Klebsiella variicola]
MRTVNYSEARQNLADVLESAVTGIPVTITRRGHKSAVIISAEEFERYQAARMDDEFAAIMAVHGDEIRELADK

Download         Length: 222 bp

>AT178160 NZ_CP083872:c202763-202697 [Escherichia coli]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1F2M0C2

References