Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 2034160..2034637 Replicon chromosome
Accession NZ_CP063401
Organism Devosia sp. SL43

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag IM737_RS09970 Protein ID WP_236899757.1
Coordinates 2034160..2034441 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag IM737_RS09975 Protein ID WP_236899758.1
Coordinates 2034446..2034637 (-) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IM737_RS09950 (IM737_09945) 2029490..2030332 - 843 WP_272906557.1 ATP-binding cassette domain-containing protein -
IM737_RS09955 (IM737_09950) 2030340..2031260 - 921 WP_236899754.1 ABC transporter permease subunit -
IM737_RS09960 (IM737_09955) 2031260..2032183 - 924 WP_236899755.1 ABC transporter permease subunit -
IM737_RS09965 (IM737_09960) 2032291..2033907 - 1617 WP_236899756.1 peptide ABC transporter substrate-binding protein -
IM737_RS09970 (IM737_09965) 2034160..2034441 - 282 WP_236899757.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IM737_RS09975 (IM737_09970) 2034446..2034637 - 192 WP_236899758.1 antitoxin Antitoxin
IM737_RS09980 (IM737_09975) 2034680..2034841 - 162 WP_236899759.1 hypothetical protein -
IM737_RS09985 (IM737_09980) 2034838..2036121 - 1284 WP_236899760.1 acetyl-CoA C-acetyltransferase -
IM737_RS09990 (IM737_09985) 2036123..2038084 - 1962 WP_236899761.1 3-hydroxyacyl-CoA dehydrogenase NAD-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10606.29 Da        Isoelectric Point: 6.7236

>T178158 WP_236899757.1 NZ_CP063401:c2034441-2034160 [Devosia sp. SL43]
MEIIWSPEAQGEVQAIVAYIADFDPVAARDIRLRLEAVVLPLAEHPYLFRSGRVLGTRELVVSPNYIIVYRVTDHVRIVS
VLHARQEYPSPRP

Download         Length: 282 bp

>T178158 NZ_CP083869:c4253359-4253174 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTCTCTCTTTTAGGAGCTGTAGTTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7099.07 Da        Isoelectric Point: 5.0492

>AT178158 WP_236899758.1 NZ_CP063401:c2034637-2034446 [Devosia sp. SL43]
MAKKLDPIISEFDTQEQAESYDRWFRAKVEKSLADPRPGIPHDQVMAELDAIIAAAEARKKTA

Download         Length: 192 bp

>AT178158 NZ_CP083869:c4253683-4253387 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References