Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 3033880..3034484 Replicon chromosome
Accession NZ_CP063400
Organism Hydrogenophaga sp. SL48

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag IM738_RS14370 Protein ID WP_236961539.1
Coordinates 3033880..3034182 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag IM738_RS14375 Protein ID WP_236961540.1
Coordinates 3034179..3034484 (+) Length 102 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IM738_RS14355 (IM738_14360) 3029553..3029774 - 222 WP_236961536.1 formate dehydrogenase -
IM738_RS14360 (IM738_14365) 3030270..3031613 + 1344 WP_236961537.1 sigma-54 dependent transcriptional regulator -
IM738_RS14365 (IM738_14370) 3031729..3033813 + 2085 WP_236961538.1 cache domain-containing protein -
IM738_RS14370 (IM738_14375) 3033880..3034182 + 303 WP_236961539.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IM738_RS14375 (IM738_14380) 3034179..3034484 + 306 WP_236961540.1 putative addiction module antidote protein Antitoxin
IM738_RS14380 (IM738_14385) 3034536..3035051 + 516 WP_236961541.1 hypothetical protein -
IM738_RS14385 (IM738_14390) 3035077..3035694 - 618 WP_236961542.1 molecular chaperone TorD family protein -
IM738_RS14390 (IM738_14395) 3035723..3037804 - 2082 WP_236966322.1 4Fe-4S binding protein -
IM738_RS14395 (IM738_14400) 3037764..3038405 - 642 WP_236961543.1 DUF3306 domain-containing protein -
IM738_RS14400 (IM738_14405) 3038467..3039267 - 801 WP_236961550.1 gamma-glutamyl-gamma-aminobutyrate hydrolase family protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(12-92)

Antitoxin

(10-95)


Sequences


Toxin        


Download         Length: 101 a.a.        Molecular weight: 11294.06 Da        Isoelectric Point: 9.6539

>T178156 WP_236961539.1 NZ_CP063400:3033880-3034182 [Hydrogenophaga sp. SL48]
VFTVLQTEDFRDWLDALKDMKAQVRIAARLRLAEAGSLGDWKSVGDGLSEMRVDVGPGYRLYFTRRQNILIVMLAGGDKS
TQAKDIKRAQKLLTQLELEP

Download         Length: 303 bp

>T178156 NZ_CP083869:c4040710-4040423 [Escherichia coli]
ATGCCAATGGAGTTTGAATGGGATGAAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTATTGTTTGATGATCCACAACATTTGTCACAGCAAGAACGCATAGAAAACGGTGAGTATCGCTGGCAGACAATCGGCC
TGGTTTACGGCATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAATCGCTATGAGCATGGTTAA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 10752.56 Da        Isoelectric Point: 10.1735

>AT178156 WP_236961540.1 NZ_CP063400:3034179-3034484 [Hydrogenophaga sp. SL48]
MSTTKMKSKLVPFDAARYLSDDTAIAEYMNAVLETGDTDLLLLALGDVARARGMAQVAKDAGLGRESLYKALTPGAKPRF
DTVVKVARALGVRLGVRPVSV

Download         Length: 306 bp

>AT178156 NZ_CP083869:c4040436-4040134 [Escherichia coli]
ATGAGCATGGTTAAACATAAACGAGGGACCTCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGCGCTGACGAA
TAAATCCGACGAAGATATTGATTACAGTGATATCCCACCTTCCAGCGATGAGCAATGGTCTAACGCCGAACGCGGTAAGT
TTTATCGGCCATTGAAAACTCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGTTGAAGCGACCAGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure

References