Detailed information of TA system TA178155

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapC-higA/VapC-HigA
• Location: 1288463..1289270
• Replicon: chromosome
• Accession: NZ_CP063400
• Organism: Hydrogenophaga sp. SL48

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: IM738_RS06160
• Protein ID: WP_236965012.1
• Coordinates: 1288463..1288879 (+)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: IM738_RS06165
• Protein ID: WP_236965013.1
• Coordinates: 1288896..1289270 (+)
• Length: 125 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IM738_RS06135 (IM738_06155)	1283964..1285958	+	1995	WP_236965007.1	acetate--CoA ligase	-
IM738_RS06140 (IM738_06160)	1286083..1286310	-	228	WP_236965008.1	hypothetical protein	-
IM738_RS06145 (IM738_06165)	1286618..1287445	-	828	WP_272907802.1	IS1595 family transposase	-
IM738_RS06150 (IM738_06170)	1287542..1287721	+	180	WP_236965010.1	hypothetical protein	-
IM738_RS06155 (IM738_06175)	1288193..1288453	+	261	WP_236965011.1	type II toxin-antitoxin system prevent-host-death family antitoxin	-
IM738_RS06160 (IM738_06180)	1288463..1288879	+	417	WP_236965012.1	type II toxin-antitoxin system VapC family toxin	Toxin
IM738_RS06165 (IM738_06185)	1288896..1289270	+	375	WP_236965013.1	helix-turn-helix domain-containing protein	Antitoxin
IM738_RS06170 (IM738_06190)	1289271..1289555	+	285	WP_236965014.1	hypothetical protein	-
IM738_RS06175 (IM738_06195)	1289568..1289810	-	243	WP_236965015.1	type II toxin-antitoxin system PrlF family antitoxin	-
IM738_RS06180 (IM738_06200)	1290093..1290398	-	306	WP_272907803.1	c-type cytochrome	-
IM738_RS06185 (IM738_06205)	1290526..1290765	+	240	WP_236965016.1	TIGR04438 family Trp-rich protein	-
IM738_RS06190 (IM738_06210)	1290873..1292732	+	1860	WP_236965017.1	dihydroxy-acid dehydratase	-
IM738_RS06195 (IM738_06215)	1292844..1293647	+	804	WP_236965018.1	prolipoprotein diacylglyceryl transferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-120)

Antitoxin

• Cro/C1-type helix-turn-helix domain (71-122)

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 15020.11 Da
• Isoelectric Point: 7.2808

>T178155 WP_236965012.1 NZ_CP063400:1288463-1288879 [Hydrogenophaga sp. SL48]
MFVLDTNVISELRHGKPNQSAQVRSWAAGQPSSRLFLSAISILELEIGIRALERRTPPQGSALRTWLSGVREAFAGRILP
FTETTAPVCASLHVPDPRSERDAMIAATAIEHGFTVVTRNVSDFVDTGVALVNPWNSP

Nucleotide

• Length: 417 bp

>T178155 NZ_CP083869:3704129-3704407 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATATTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin

Protein

• Length: 125 a.a.
• Molecular weight: 13948.57 Da
• Isoelectric Point: 4.5567

>AT178155 WP_236965013.1 NZ_CP063400:1288896-1289270 [Hydrogenophaga sp. SL48]
VERVSKRTAGAIHAQAEYDRAVEFMNQLLDVVGDDEEHELAGMLELLGQLVEDFEHSHYSLPDAEPGQVLRFLMDQHELK
RADLAHEIGFQSVISEMLNGHRQINAHQADSLAQRFGVSPSVFI

Nucleotide

• Length: 375 bp

>AT178155 NZ_CP083869:3703866-3704126 [Escherichia coli]
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCAGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCATTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA