Detailed information of TA system TA178154

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/-
• Location: 681111..681691
• Replicon: chromosome
• Accession: NZ_CP063400
• Organism: Hydrogenophaga sp. SL48

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: IM738_RS03270
• Protein ID: WP_236964465.1
• Coordinates: 681111..681491 (-)
• Length: 127 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: IM738_RS03275
• Protein ID: WP_236964466.1
• Coordinates: 681488..681691 (-)
• Length: 68 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IM738_RS03240 (IM738_03255)	676652..678145	-	1494	WP_236964459.1	potassium/proton antiporter	-
IM738_RS03245 (IM738_03260)	678222..679319	+	1098	WP_236964460.1	enolase C-terminal domain-like protein	-
IM738_RS03250 (IM738_03265)	679330..679713	-	384	WP_236964461.1	VOC family protein	-
IM738_RS03255 (IM738_03270)	679865..680296	+	432	WP_236964462.1	DUF2267 domain-containing protein	-
IM738_RS03260 (IM738_03275)	680293..680805	+	513	WP_236964463.1	GNAT family N-acetyltransferase	-
IM738_RS03265 (IM738_03280)	680931..681095	-	165	WP_236964464.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
IM738_RS03270 (IM738_03285)	681111..681491	-	381	WP_236964465.1	VapC toxin family PIN domain ribonuclease	Toxin
IM738_RS03275 (IM738_03290)	681488..681691	-	204	WP_236964466.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
IM738_RS03280 (IM738_03295)	681834..682109	+	276	WP_236964467.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
IM738_RS03285 (IM738_03300)	682115..682435	+	321	WP_236964468.1	type II toxin-antitoxin system RelE/ParE family toxin	-
IM738_RS03290 (IM738_03305)	682538..683074	+	537	WP_236964469.1	hypothetical protein	-
IM738_RS03295 (IM738_03310)	683127..683792	+	666	WP_236964470.1	hypothetical protein	-
IM738_RS03300 (IM738_03315)	683874..684477	-	604	Protein_652	acyl-CoA dehydrogenase family protein	-
IM738_RS03305 (IM738_03320)	684584..685843	+	1260	WP_236964471.1	AAA family ATPase	-
IM738_RS03310 (IM738_03325)	685840..686415	+	576	WP_236964472.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin YafO (27-130)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 127 a.a.
• Molecular weight: 13619.74 Da
• Isoelectric Point: 6.0689

>T178154 WP_236964465.1 NZ_CP063400:c681491-681111 [Hydrogenophaga sp. SL48]
MTAVLVDTSVWVDHFRSRNEELANLLVQDAVLTHPWVRAELACGTPPARVQTLADLAALQPAKVATVDEVMAFVERERLY
GQGCGLVDLGLLASALITPGARLWTLDRRLVGLAERLGVAHTAATH

Nucleotide

• Length: 381 bp

>T178154 NZ_CP083869:c3698067-3697669 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCCTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGAGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGGGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin

Protein

• Length: 68 a.a.
• Molecular weight: 7578.67 Da
• Isoelectric Point: 5.0807

>AT178154 WP_236964466.1 NZ_CP063400:c681691-681488 [Hydrogenophaga sp. SL48]
MRTTVTIDDALYERALQVADPSMDKADLFREVFRTFVRVQSAKRLAALGAAAPEMAEIPRRREEPAE

Nucleotide

• Length: 204 bp

>AT178154 NZ_CP083869:c3698363-3698070 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA