Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 403313..403961 Replicon chromosome
Accession NZ_CP063400
Organism Hydrogenophaga sp. SL48

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag IM738_RS01910 Protein ID WP_236964215.1
Coordinates 403313..403717 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag IM738_RS01915 Protein ID WP_236964216.1
Coordinates 403728..403961 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IM738_RS01895 (IM738_01910) 398735..400042 + 1308 WP_236964212.1 hypothetical protein -
IM738_RS01900 (IM738_01915) 400072..401655 - 1584 WP_236964213.1 bifunctional aminoglycoside phosphotransferase/ATP-binding protein -
IM738_RS01905 (IM738_01920) 401761..403296 + 1536 WP_236964214.1 AMP-binding protein -
IM738_RS01910 (IM738_01925) 403313..403717 - 405 WP_236964215.1 type II toxin-antitoxin system VapC family toxin Toxin
IM738_RS01915 (IM738_01930) 403728..403961 - 234 WP_236964216.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
IM738_RS01920 (IM738_01935) 404114..404701 - 588 WP_236964217.1 NAD(P)H-dependent oxidoreductase -
IM738_RS01925 (IM738_01940) 404804..405385 + 582 WP_236964218.1 TetR/AcrR family transcriptional regulator -
IM738_RS01930 (IM738_01945) 405519..406283 - 765 WP_236964219.1 hypothetical protein -
IM738_RS01935 (IM738_01950) 406395..406931 - 537 WP_236964220.1 GNAT family N-acetyltransferase -
IM738_RS01940 (IM738_01955) 407098..407301 + 204 WP_236964221.1 putative motility protein -
IM738_RS01945 (IM738_01960) 407316..408833 - 1518 WP_236964222.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-123)

Antitoxin

SpoVT-AbrB domain

(7-55)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 14614.86 Da        Isoelectric Point: 6.4868

>T178153 WP_236964215.1 NZ_CP063400:c403717-403313 [Hydrogenophaga sp. SL48]
MLKYLLDTNIVIYVIKRRPVEVMGVFNENAGRMAISAITLSELYHGAEKSAKVAQNLAVVEEFASLLEVLPYGAKASQHY
GALRAELEKAGRPIGVNDLHIAAHARSEGLTLVTNNVGEFERVPGLLLENWVGS

Download         Length: 405 bp

>T178153 NZ_CP083869:3441861-3442079 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8622.82 Da        Isoelectric Point: 9.0010

>AT178153 WP_236964216.1 NZ_CP063400:c403961-403728 [Hydrogenophaga sp. SL48]
MSITTVFTNNRSQAVRLPADVRLPEGVKKVQVRARGMDRIISPVGHTWDAFFLNGPMASDDFMAERAVQAQAERESF

Download         Length: 234 bp

>AT178153 NZ_CP083869:3441461-3441835 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References