Detailed information of TA system TA178143

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Xre(antitoxin)
• Location: 4632117..4633375
• Replicon: chromosome
• Accession: NZ_CP063396
• Organism: Pseudomonas aeruginosa strain ST167_d26burn

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: IPV38_RS21360
• Protein ID: WP_003449003.1
• Coordinates: 4632117..4632872 (-)
• Length: 252 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: V6AJU7
• Locus tag: IPV38_RS21365
• Protein ID: WP_003086329.1
• Coordinates: 4633007..4633375 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IPV38_RS21350 (IPV38_21335)	4627290..4629833	+	2544	WP_003112526.1	acyl-homoserine-lactone acylase QuiP	-
IPV38_RS21355 (IPV38_21340)	4629988..4631349	-	1362	WP_073647918.1	DNA recombination protein RmuC	-
IPV38_RS21360 (IPV38_21345)	4632117..4632872	-	756	WP_003449003.1	RES family NAD+ phosphorylase	Toxin
IPV38_RS21365 (IPV38_21350)	4633007..4633375	-	369	WP_003086329.1	DUF2384 domain-containing protein	Antitoxin
IPV38_RS21370 (IPV38_21355)	4633448..4634734	-	1287	WP_003449000.1	FAD-binding oxidoreductase	-
IPV38_RS21375 (IPV38_21360)	4634790..4636283	-	1494	WP_003086325.1	aldehyde dehydrogenase family protein	-
IPV38_RS21380 (IPV38_21365)	4636458..4636934	+	477	WP_003112531.1	hypothetical protein	-
IPV38_RS21385 (IPV38_21370)	4636937..4637212	-	276	WP_010792073.1	zinc ribbon domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (63-207)

Antitoxin

• Cro/C1-type helix-turn-helix domain (23-47)

Sequences

Toxin

Protein

• Length: 252 a.a.
• Molecular weight: 28292.45 Da
• Isoelectric Point: 7.7294

>T178143 WP_003449003.1 NZ_CP063396:c4632872-4632117 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMVVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGTAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Nucleotide

• Length: 756 bp

>T178143 NZ_CP083869:753745-754041 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13367.63 Da
• Isoelectric Point: 9.9874

>AT178143 WP_003086329.1 NZ_CP063396:c4633375-4633007 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Nucleotide

• Length: 369 bp

>AT178143 NZ_CP083869:754043-754438 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Structures

Antitoxin

• AlphaFold DB: V6AJU7