Detailed information of TA system TA178142

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/-
• Location: 3690522..3691743
• Replicon: chromosome
• Accession: NZ_CP063396
• Organism: Pseudomonas aeruginosa strain ST167_d26burn

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: IPV38_RS16965
• Protein ID: WP_003160088.1
• Coordinates: 3691165..3691743 (+)
• Length: 193 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: IPV38_RS16960
• Protein ID: WP_003088112.1
• Coordinates: 3690522..3691076 (+)
• Length: 185 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IPV38_RS16935 (IPV38_16940)	3686090..3686641	+	552	WP_003102727.1	XRE family transcriptional regulator	-
IPV38_RS16940 (IPV38_16945)	3686638..3687036	-	399	WP_003088123.1	NADH-quinone oxidoreductase subunit A	-
IPV38_RS16945 (IPV38_16950)	3687049..3687372	-	324	WP_003102734.1	multidrug efflux SMR transporter	-
IPV38_RS16950 (IPV38_16955)	3687703..3688164	+	462	WP_003102736.1	(2Fe-2S)-binding protein	-
IPV38_RS16955 (IPV38_16960)	3688169..3690364	+	2196	WP_034010345.1	xanthine dehydrogenase family protein molybdopterin-binding subunit	-
IPV38_RS16960 (IPV38_16965)	3690522..3691076	+	555	WP_003088112.1	helix-turn-helix transcriptional regulator	Antitoxin
IPV38_RS16965 (IPV38_16970)	3691165..3691743	+	579	WP_003160088.1	HD domain-containing protein	Toxin
IPV38_RS16970 (IPV38_16975)	3691852..3693039	-	1188	WP_003102741.1	HlyD family efflux transporter periplasmic adaptor subunit	-
IPV38_RS16975 (IPV38_16980)	3693029..3695200	-	2172	WP_003114950.1	type I secretion system permease/ATPase	-
IPV38_RS16980 (IPV38_16985)	3695190..3696275	-	1086	WP_243496770.1	TolC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HD domain (16-170)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-62)

Sequences

Toxin

Protein

• Length: 193 a.a.
• Molecular weight: 21816.65 Da
• Isoelectric Point: 5.1625

>T178142 WP_003160088.1 NZ_CP063396:3691165-3691743 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQCLAARRDA

Nucleotide

• Length: 579 bp

>T178142 NZ_CP083869:c647597-647133 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAGACAGAAGAACCCCATTGA

Antitoxin

Protein

• Length: 185 a.a.
• Molecular weight: 20454.63 Da
• Isoelectric Point: 8.1590

>AT178142 WP_003088112.1 NZ_CP063396:3690522-3691076 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Nucleotide

• Length: 555 bp

>AT178142 NZ_CP083869:c647932-647597 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA