Detailed information of TA system TA178137

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Xre(antitoxin)
• Location: 4632115..4633373
• Replicon: chromosome
• Accession: NZ_CP063395
• Organism: Pseudomonas aeruginosa strain ST167_d57blood

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: IPV39_RS21360
• Protein ID: WP_003449003.1
• Coordinates: 4632115..4632870 (-)
• Length: 252 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: V6AJU7
• Locus tag: IPV39_RS21365
• Protein ID: WP_003086329.1
• Coordinates: 4633005..4633373 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IPV39_RS21350 (IPV39_21345)	4627288..4629831	+	2544	WP_003112526.1	acyl-homoserine-lactone acylase QuiP	-
IPV39_RS21355 (IPV39_21350)	4629986..4631347	-	1362	WP_073647918.1	DNA recombination protein RmuC	-
IPV39_RS21360 (IPV39_21355)	4632115..4632870	-	756	WP_003449003.1	RES family NAD+ phosphorylase	Toxin
IPV39_RS21365 (IPV39_21360)	4633005..4633373	-	369	WP_003086329.1	DUF2384 domain-containing protein	Antitoxin
IPV39_RS21370 (IPV39_21365)	4633446..4634732	-	1287	WP_003449000.1	FAD-binding oxidoreductase	-
IPV39_RS21375 (IPV39_21370)	4634788..4636281	-	1494	WP_003086325.1	aldehyde dehydrogenase family protein	-
IPV39_RS21380 (IPV39_21375)	4636456..4636932	+	477	WP_003112531.1	hypothetical protein	-
IPV39_RS21385 (IPV39_21380)	4636935..4637210	-	276	WP_010792073.1	zinc ribbon domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (63-207)

Antitoxin

• Cro/C1-type helix-turn-helix domain (23-47)

Sequences

Toxin

Protein

• Length: 252 a.a.
• Molecular weight: 28292.45 Da
• Isoelectric Point: 7.7294

>T178137 WP_003449003.1 NZ_CP063395:c4632870-4632115 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMVVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGTAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Nucleotide

• Length: 756 bp

>T178137 NZ_CP083867:63032-63307 [Escherichia coli]
ATGGAACTGAAGTGGACCAGTAAGGCGCTTTCTGATTTGTCGCGGTTATTTGATTTTCTGGTGCTGGCCAGTAAACCTGC
TGCCGCCAGAACGGTACAGTCCCTGACACAGGCACCGGTCATTCTGTTAACTCATCCACGTATGGGAGAACAGTTGTTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTGCTGGCGAGTACGAAATCCGTTACGAAATTAATGGCCAGACTATTTAT
GTATTGCGTCTGTGGCACACACGAGAAAACAGGTAG

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13367.63 Da
• Isoelectric Point: 9.9874

>AT178137 WP_003086329.1 NZ_CP063395:c4633373-4633005 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Nucleotide

• Length: 369 bp

>AT178137 NZ_CP083867:62748-63032 [Escherichia coli]
ATGCAAATGAAAAACAATGCCGCACAAGCAACAAAAGTAATTACCGCGCATGTGCCATTACCTATGGCTGATAAAGTCGA
CCAGATGGCCGCCAGACTGGAACGTTCCCGGGGCTGGGTTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAGGAGGAGG
AGCGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGACATCCGGACAGGTTATCGACCATCAGGCTGTACAGGCCTGG
TCGGACAGCCTCAGTACTGACAATCCGTTACCGGTGCCACGCTGA

Structures

Antitoxin

• AlphaFold DB: V6AJU7