178136

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3690522..3691743 Replicon chromosome
Accession NZ_CP063395
Organism Pseudomonas aeruginosa strain ST167_d57blood

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag IPV39_RS16970 Protein ID WP_003160088.1
Coordinates 3691165..3691743 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag IPV39_RS16965 Protein ID WP_003088112.1
Coordinates 3690522..3691076 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IPV39_RS16940 (IPV39_16945) 3686090..3686641 + 552 WP_003102727.1 XRE family transcriptional regulator -
IPV39_RS16945 (IPV39_16950) 3686638..3687036 - 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
IPV39_RS16950 (IPV39_16955) 3687049..3687372 - 324 WP_003102734.1 multidrug efflux SMR transporter -
IPV39_RS16955 (IPV39_16960) 3687703..3688164 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
IPV39_RS16960 (IPV39_16965) 3688169..3690364 + 2196 WP_034010345.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
IPV39_RS16965 (IPV39_16970) 3690522..3691076 + 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
IPV39_RS16970 (IPV39_16975) 3691165..3691743 + 579 WP_003160088.1 HD domain-containing protein Toxin
IPV39_RS16975 (IPV39_16980) 3691852..3693039 - 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
IPV39_RS16980 (IPV39_16985) 3693029..3695200 - 2172 WP_003114950.1 type I secretion system permease/ATPase -
IPV39_RS16985 (IPV39_16990) 3695190..3696275 - 1086 WP_243496770.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21816.65 Da        Isoelectric Point: 5.1625

>T178136 WP_003160088.1 NZ_CP063395:3691165-3691743 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQCLAARRDA

Download         Length: 579 bp

>T178136 NZ_CP083863:c192167-191880 [Enterobacter kobei]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT178136 WP_003088112.1 NZ_CP063395:3690522-3691076 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp

>AT178136 NZ_CP083863:c192406-192167 [Enterobacter kobei]
ATGGGTAGCATTAACCTACGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGCGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGACTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References