Detailed information of TA system TA178134

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 144432..144937
• Replicon: chromosome
• Accession: NZ_CP063395
• Organism: Pseudomonas aeruginosa strain ST167_d57blood

Toxin (Protein)

• Gene name: parE
• Uniprot ID: A0A069QL22
• Locus tag: IPV39_RS00660
• Protein ID: WP_003121619.1
• Coordinates: 144432..144713 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q9I707
• Locus tag: IPV39_RS00665
• Protein ID: WP_003112628.1
• Coordinates: 144710..144937 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IPV39_RS00635 (IPV39_00635)	139683..141032	+	1350	WP_003142411.1	C4-dicarboxylate transporter DctA	-
IPV39_RS00640 (IPV39_00640)	141081..141767	+	687	WP_003083762.1	FadR/GntR family transcriptional regulator	-
IPV39_RS00645 (IPV39_00645)	141868..142602	+	735	WP_003117208.1	GntR family transcriptional regulator	-
IPV39_RS00650 (IPV39_00650)	142782..143192	+	411	WP_003101225.1	aegerolysin family protein	-
IPV39_RS00655 (IPV39_00655)	143224..144132	-	909	WP_016561475.1	LysR family transcriptional regulator	-
IPV39_RS00660 (IPV39_00660)	144432..144713	-	282	WP_003121619.1	type II toxin-antitoxin system toxin ParE	Toxin
IPV39_RS00665 (IPV39_00665)	144710..144937	-	228	WP_003112628.1	CopG family ribbon-helix-helix protein	Antitoxin
IPV39_RS00670 (IPV39_00670)	145113..145733	-	621	WP_003101226.1	hypothetical protein	-
IPV39_RS00675 (IPV39_00675)	145834..146334	+	501	WP_003101228.1	LEA type 2 family protein	-
IPV39_RS00680 (IPV39_00680)	146407..146748	+	342	WP_003101229.1	zinc ribbon domain-containing protein YjdM	-
IPV39_RS00685 (IPV39_00685)	146830..148257	-	1428	WP_003083784.1	GABA permease	-
IPV39_RS00690 (IPV39_00690)	148426..149919	-	1494	WP_043105480.1	CoA-acylating methylmalonate-semialdehyde dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-87)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10492.22 Da
• Isoelectric Point: 10.0435

>T178134 WP_003121619.1 NZ_CP063395:c144713-144432 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDTIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Nucleotide

• Length: 282 bp

>T178134 NZ_CP083862:4299671-4300048 [Enterobacter kobei]
ATGCAAACACAACCTGTTCCTCCGAAACGGGAGGTTTCGCCACGCCCGTCACCCGTGGCGATCTGGCAGCGCCTCCTGAG
TCACCTGCTGGACCGTCACTACGGTCTGACGCTCAACGACACGCCATTTGGCAAAGATGGTGTGATCCAAGAGCATATCG
ATGCCGGTATCTCACTGTGCGACGCGGTGAATTTCATCGTGGAGAAATACGACCTGGTACGCACTGATCGTCGCGGTTTT
AACGCGGAAACTCAGTCGCCGCTTCTCACCAGTATCGATATTCTCCGCGCCCGCAAAGCCACCGGGCTGATGACCCGTCA
TAGCTACAGGGCCGTTACCGACATCACCACCGGCAAATACCGTGAGGTGCAACCATGA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8568.64 Da
• Isoelectric Point: 5.5740

>AT178134 WP_003112628.1 NZ_CP063395:c144937-144710 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHIEIEKRWGLQ

Nucleotide

• Length: 228 bp

>AT178134 NZ_CP083862:4299262-4299621 [Enterobacter kobei]
TTGTCGAATACAATACCGCCTGTAAACCACGATATCGCCGCCCCTTGGTGGGGGCTTAAACGCGATATCACCCCCTGTTT
TGGCGCACGTCTGGTGCAGGAGGGCAACCGGCTGCATTACCTGAACGACCGCGCCAGCATCACCGGCACCTTCAGCGACG
CGGATTTACGCCATCTCGACCAGGCATTCCCGCTACTGCTGAAGCAACTGGAGCTGATGCTGCTTTCCGGTGAGCTGAAT
CCCCGTCATCAGCACTGCGTCACGCTGTATGCAAAAGGGCTGATATGCGAGGCCGACAGCCTCGGCTCGCACGGGTACGT
CTATCTCGCAATTTACCCGACACCTGCAACAACAGAATAA

Structures

Toxin

• AlphaFold DB: A0A069QL22

Antitoxin

• AlphaFold DB: Q9I707