Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 144903..145408 Replicon chromosome
Accession NZ_CP063394
Organism Pseudomonas aeruginosa strain ST167_d67burn1

Toxin (Protein)


Gene name parE Uniprot ID A0A069QL22
Locus tag IPV40_RS00660 Protein ID WP_003121619.1
Coordinates 144903..145184 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q9I707
Locus tag IPV40_RS00665 Protein ID WP_003112628.1
Coordinates 145181..145408 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IPV40_RS00635 (IPV40_00635) 140154..141503 + 1350 WP_003142411.1 C4-dicarboxylate transporter DctA -
IPV40_RS00640 (IPV40_00640) 141552..142238 + 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
IPV40_RS00645 (IPV40_00645) 142339..143073 + 735 WP_003117208.1 GntR family transcriptional regulator -
IPV40_RS00650 (IPV40_00650) 143253..143663 + 411 WP_003101225.1 aegerolysin family protein -
IPV40_RS00655 (IPV40_00655) 143695..144603 - 909 WP_016561475.1 LysR family transcriptional regulator -
IPV40_RS00660 (IPV40_00660) 144903..145184 - 282 WP_003121619.1 type II toxin-antitoxin system toxin ParE Toxin
IPV40_RS00665 (IPV40_00665) 145181..145408 - 228 WP_003112628.1 CopG family ribbon-helix-helix protein Antitoxin
IPV40_RS00670 (IPV40_00670) 145584..146204 - 621 WP_003101226.1 hypothetical protein -
IPV40_RS00675 (IPV40_00675) 146305..146805 + 501 WP_003101228.1 LEA type 2 family protein -
IPV40_RS00680 (IPV40_00680) 146878..147219 + 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
IPV40_RS00685 (IPV40_00685) 147301..148728 - 1428 WP_003083784.1 GABA permease -
IPV40_RS00690 (IPV40_00690) 148897..150390 - 1494 WP_043105480.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10492.22 Da        Isoelectric Point: 10.0435

>T178128 WP_003121619.1 NZ_CP063394:c145184-144903 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDTIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T178128 NZ_CP083862:c1126330-1125968 [Enterobacter kobei]
ATGTGGAATGTCGAGACAACGGACATATTTGATCAATGGTACTTCGAACAAACAACAGCATTAAAAGAAGATGTGCTAGC
GATGATGCATATTCTTGCTGAGTTTGGCCCAACGCTTGGGCGGCCATACGTAGATACCGTGAAGGCTTCAGCCTATGCGA
ACATGAAGGAATTACGGATTCAACATGCGGGAAATCCCATCAGAGCTTTTTTTGCTTTTGATCCTGACCGTAAGGCAATT
GTGCTCTGTGCTGGAGACAAAACCGGTTGCAATCAAAAACGGTTTTATAACGAAATGATTACGCTGGCTGACGTTGAGTA
CAGCAGACATCTGGCGGATAAGGAGGCCATATGGCAACGCTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8568.64 Da        Isoelectric Point: 5.5740

>AT178128 WP_003112628.1 NZ_CP063394:c145408-145181 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHIEIEKRWGLQ

Download         Length: 228 bp

>AT178128 NZ_CP083862:c1125980-1125681 [Enterobacter kobei]
ATGGCAACGCTAAAAGAACTCATGGCACAACAGAGCGCGGAAAGTCAGGAGCGTATTGCGGCTAAAGTTGATGTAATACG
AAGAATTGTTGCCCTGAACCAACTGCGGGAAGAGCTCAATATTTCGCAGACAGAACTGGCCGCGGCAATGGGGGTAAAAC
AACCCACTGTGGCAAAAATCGAACAGCCGGGAAACGATCCCCGGCTTTCAACACTCAAACGCTATGTCAGTGCGCTCGGC
GGTGAAATGAGCATTGATGTGACGTTACCGAATGGGAAACGAATAGCGTTTCAGATTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A069QL22

Antitoxin

Source ID Structure
PDB 6XRW
AlphaFold DB Q9I707

References