Detailed information of TA system TA178125

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Xre(antitoxin)
• Location: 4632103..4633361
• Replicon: chromosome
• Accession: NZ_CP063393
• Organism: Pseudomonas aeruginosa strain ST167_d67burn2

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: IPV41_RS21360
• Protein ID: WP_003449003.1
• Coordinates: 4632103..4632858 (-)
• Length: 252 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: V6AJU7
• Locus tag: IPV41_RS21365
• Protein ID: WP_003086329.1
• Coordinates: 4632993..4633361 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IPV41_RS21350 (IPV41_21345)	4627276..4629819	+	2544	WP_003112526.1	acyl-homoserine-lactone acylase QuiP	-
IPV41_RS21355 (IPV41_21350)	4629974..4631335	-	1362	WP_073647918.1	DNA recombination protein RmuC	-
IPV41_RS21360 (IPV41_21355)	4632103..4632858	-	756	WP_003449003.1	RES family NAD+ phosphorylase	Toxin
IPV41_RS21365 (IPV41_21360)	4632993..4633361	-	369	WP_003086329.1	DUF2384 domain-containing protein	Antitoxin
IPV41_RS21370 (IPV41_21365)	4633434..4634720	-	1287	WP_003449000.1	FAD-binding oxidoreductase	-
IPV41_RS21375 (IPV41_21370)	4634776..4636269	-	1494	WP_003086325.1	aldehyde dehydrogenase family protein	-
IPV41_RS21380 (IPV41_21375)	4636444..4636920	+	477	WP_003112531.1	hypothetical protein	-
IPV41_RS21385 (IPV41_21380)	4636923..4637198	-	276	WP_010792073.1	zinc ribbon domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (63-207)

Antitoxin

• Cro/C1-type helix-turn-helix domain (23-47)

Sequences

Toxin

Protein

• Length: 252 a.a.
• Molecular weight: 28292.45 Da
• Isoelectric Point: 7.7294

>T178125 WP_003449003.1 NZ_CP063393:c4632858-4632103 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMVVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGTAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Nucleotide

• Length: 756 bp

>T178125 NZ_CP083862:c63956-63606 [Enterobacter kobei]
ATGTGGACGGTACTGTTCGGAAAGGTGTTTGAGCTATGGTTGCTTGAACAGGAAGAAGGGTTACAGGAAAAGGTACTGGC
AGACATGCTAAATCTACAAAACTATGGACCTCGTCTTCCTCGTCCCTATGCCGATACTGTAAAAGGCTCGCAATATAACA
ATATGAAAGAGTTACGTGTTCAATACGCTGGTCGTCCGATTCGTGCTTTATTCGCATTTGACCCCGAACGTCAGGCGATT
GTGCTTTGCGCAGGCAACAAGAGTAACGACAAGGCATTTTATGAAAAACTCATTCGCATTGCAGATGATGAATTTACCCG
GCATCTGACAAGCCTGGAGACAGCCAAGTGA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13367.63 Da
• Isoelectric Point: 9.9874

>AT178125 WP_003086329.1 NZ_CP063393:c4633361-4632993 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Nucleotide

• Length: 369 bp

>AT178125 NZ_CP083862:c63609-63310 [Enterobacter kobei]
GTGAAAACACTAAATGAATTAATTGCATCACGCTCACCGGAAAGCCAACAACGAATTAAAGAAATGGCAGAGGAAATGAT
CCTTGAAACGGGTTTGCAACTTTTACGTGAAGAGCTCAGGCTTTCGCAAAAAAATGTTGCCGAGCTAATGGGGGTGAGCC
AGCCCGCAGTAACACAAATAGAGCAACGTGGAAATGAACTAAAAATTGCCACGCTTAAGCGCTACATTGAGGCAATGGGT
GGGAAACTTTGTATCGACGTTGAACTTCCAACAGGAAAACGCGTTGCGTTTCATATCTAA

Structures

Antitoxin

• AlphaFold DB: V6AJU7