Detailed information of TA system TA178113

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Xre(antitoxin)
• Location: 4632116..4633374
• Replicon: chromosome
• Accession: NZ_CP063391
• Organism: Pseudomonas aeruginosa strain ST167_d68blood2

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: IPV43_RS21365
• Protein ID: WP_003449003.1
• Coordinates: 4632116..4632871 (-)
• Length: 252 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: V6AJU7
• Locus tag: IPV43_RS21370
• Protein ID: WP_003086329.1
• Coordinates: 4633006..4633374 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IPV43_RS21355 (IPV43_21345)	4627289..4629832	+	2544	WP_003112526.1	acyl-homoserine-lactone acylase QuiP	-
IPV43_RS21360 (IPV43_21350)	4629987..4631348	-	1362	WP_073647918.1	DNA recombination protein RmuC	-
IPV43_RS21365 (IPV43_21355)	4632116..4632871	-	756	WP_003449003.1	RES family NAD+ phosphorylase	Toxin
IPV43_RS21370 (IPV43_21360)	4633006..4633374	-	369	WP_003086329.1	DUF2384 domain-containing protein	Antitoxin
IPV43_RS21375 (IPV43_21365)	4633447..4634733	-	1287	WP_003449000.1	FAD-binding oxidoreductase	-
IPV43_RS21380 (IPV43_21370)	4634789..4636282	-	1494	WP_003086325.1	aldehyde dehydrogenase family protein	-
IPV43_RS21385 (IPV43_21375)	4636457..4636933	+	477	WP_003112531.1	hypothetical protein	-
IPV43_RS21390 (IPV43_21380)	4636936..4637211	-	276	WP_010792073.1	zinc ribbon domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (63-207)

Antitoxin

• Cro/C1-type helix-turn-helix domain (23-47)

Sequences

Toxin

Protein

• Length: 252 a.a.
• Molecular weight: 28292.45 Da
• Isoelectric Point: 7.7294

>T178113 WP_003449003.1 NZ_CP063391:c4632871-4632116 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMVVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGTAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Nucleotide

• Length: 756 bp

>T178113 NZ_CP083855:c11762-11346 [Enterobacter roggenkampii]
GTGAACAAGACCTATATGCTCGACACCTGTATCTGCTCGTTCATCATGCGCGAGCAGCCGGAAGCCGTCCTGAAGCGCCT
GGAGCTGGCGGTGCTGCGCGGCCAGCGCATCGTTGTCTCGGCCATCACTTATTCTGAAATGCGCTTCGGGGCCACCGGCC
CGAAGGCCTCCCCGCGCCACGTCGAGCTGGTCGACGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCT
GCGGTGGACGCCACCACGGAGATTAAGGTGGCGCTGCGAATGGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGGCACGCCATCGCCGCCGGTGCCGTGCTGGTGACGAATAATACGCGGGAATTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13367.63 Da
• Isoelectric Point: 9.9874

>AT178113 WP_003086329.1 NZ_CP063391:c4633374-4633006 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Nucleotide

• Length: 369 bp

>AT178113 NZ_CP083855:c11989-11759 [Enterobacter roggenkampii]
ATGAGAACTGTATCCATTTTTAAAAACGGCAATAACCGCGCCATTCGTCTGCCCCGCGATCTGGATTTTGAGGGAGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATTATTTTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGTTCG
AGAAGGCAGACCCGGACTTTATGGCGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGATTTAACCTGTGA

Structures

Antitoxin

• AlphaFold DB: V6AJU7