178110

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 144432..144937 Replicon chromosome
Accession NZ_CP063391
Organism Pseudomonas aeruginosa strain ST167_d68blood2

Toxin (Protein)


Gene name parE Uniprot ID A0A069QL22
Locus tag IPV43_RS00660 Protein ID WP_003121619.1
Coordinates 144432..144713 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q9I707
Locus tag IPV43_RS00665 Protein ID WP_003112628.1
Coordinates 144710..144937 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IPV43_RS00635 (IPV43_00635) 139683..141032 + 1350 WP_003142411.1 C4-dicarboxylate transporter DctA -
IPV43_RS00640 (IPV43_00640) 141081..141767 + 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
IPV43_RS00645 (IPV43_00645) 141868..142602 + 735 WP_003117208.1 GntR family transcriptional regulator -
IPV43_RS00650 (IPV43_00650) 142782..143192 + 411 WP_003101225.1 aegerolysin family protein -
IPV43_RS00655 (IPV43_00655) 143224..144132 - 909 WP_016561475.1 LysR family transcriptional regulator -
IPV43_RS00660 (IPV43_00660) 144432..144713 - 282 WP_003121619.1 type II toxin-antitoxin system toxin ParE Toxin
IPV43_RS00665 (IPV43_00665) 144710..144937 - 228 WP_003112628.1 CopG family ribbon-helix-helix protein Antitoxin
IPV43_RS00670 (IPV43_00670) 145113..145733 - 621 WP_003101226.1 hypothetical protein -
IPV43_RS00675 (IPV43_00675) 145834..146334 + 501 WP_003101228.1 LEA type 2 family protein -
IPV43_RS00680 (IPV43_00680) 146407..146748 + 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
IPV43_RS00685 (IPV43_00685) 146830..148257 - 1428 WP_003083784.1 GABA permease -
IPV43_RS00690 (IPV43_00690) 148426..149919 - 1494 WP_043105480.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10492.22 Da        Isoelectric Point: 10.0435

>T178110 WP_003121619.1 NZ_CP063391:c144713-144432 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDTIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T178110 NZ_CP083853:c4664414-4664043 [Enterobacter roggenkampii]
ATGGAGCACATGGCAGTGTTTGATACCAATATTCTCATTGATCTCTTCAACAACCGTGTTGAAGCTGCGGATGCGATTGA
GAATACCGCGTCGCATCGTGCCATCAGCTTAATTACCTGGATGGAAGTGATGGTGGGCGCTCGCAGGCATGGTCATGAAG
CGAAAACGGCAGCCGTGATGGGCGCTTTTGAAATTATTGATGTGTCTCGGGATATCGCGGAAAGAAGCGTTTTACTACGT
GAGAAGCATGGAATGAAACTGCCTGATGCTATCATCCTAGCTACAGCGCAGAGCAGAAAATGTCCGTTGGTTTCTCGCAA
CACGAAAGATTTTGCGGGTATTGACGAGGTCCTTACGCCTTACCAGGTGTAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8568.64 Da        Isoelectric Point: 5.5740

>AT178110 WP_003112628.1 NZ_CP063391:c144937-144710 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHIEIEKRWGLQ

Download         Length: 228 bp

>AT178110 NZ_CP083853:c4664659-4664417 [Enterobacter roggenkampii]
ATGAGCGTTTTGGCGGAACTTGATATGGGCAGAATACTTATCGATTTGTCTGATGACGTGATTCAACGTTTGGATAACCT
CAAGCAATTGCGAAATCAACCACGTGCTGAACTGCTTCGCGAAGCGATAGAGCTGTATCTCGACCAGCAGAGTTCTTCTG
TTATCCGAAATGCGCTTGGTCTGTGGGGAGACAGAAAAGAGGACGGGCTTGAGTATGAACGCAAGCTGCGTGAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A069QL22

Antitoxin

Source ID Structure
AlphaFold DB Q9I707

References