Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/- |
| Location | 3615244..3616464 | Replicon | chromosome |
| Accession | NZ_CP063390 | ||
| Organism | Pseudomonas aeruginosa strain ST1076_d97burn1 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | A0A0H2Z8V4 |
| Locus tag | IPV44_RS16610 | Protein ID | WP_003110488.1 |
| Coordinates | 3615886..3616464 (+) | Length | 193 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | - |
| Locus tag | IPV44_RS16605 | Protein ID | WP_003132728.1 |
| Coordinates | 3615244..3615798 (+) | Length | 185 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| IPV44_RS16580 (IPV44_16575) | 3610812..3611363 | + | 552 | WP_031685890.1 | XRE family transcriptional regulator | - |
| IPV44_RS16585 (IPV44_16580) | 3611360..3611758 | - | 399 | WP_003088123.1 | NADH-quinone oxidoreductase subunit A | - |
| IPV44_RS16590 (IPV44_16585) | 3611771..3612094 | - | 324 | WP_003102734.1 | multidrug efflux SMR transporter | - |
| IPV44_RS16595 (IPV44_16590) | 3612425..3612886 | + | 462 | WP_003102736.1 | (2Fe-2S)-binding protein | - |
| IPV44_RS16600 (IPV44_16595) | 3612891..3615086 | + | 2196 | WP_033957494.1 | xanthine dehydrogenase family protein molybdopterin-binding subunit | - |
| IPV44_RS16605 (IPV44_16600) | 3615244..3615798 | + | 555 | WP_003132728.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| IPV44_RS16610 (IPV44_16605) | 3615886..3616464 | + | 579 | WP_003110488.1 | HD domain-containing protein | Toxin |
| IPV44_RS16615 (IPV44_16610) | 3616574..3617761 | - | 1188 | WP_003110489.1 | HlyD family efflux transporter periplasmic adaptor subunit | - |
| IPV44_RS16620 (IPV44_16615) | 3617751..3619922 | - | 2172 | WP_033957491.1 | type I secretion system permease/ATPase | - |
| IPV44_RS16625 (IPV44_16620) | 3619912..3621189 | - | 1278 | WP_003088104.1 | TolC family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 193 a.a. Molecular weight: 21913.75 Da Isoelectric Point: 5.3655
>T178107 WP_003110488.1 NZ_CP063390:3615886-3616464 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDTPLRDRLLALWDEYERGETAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDTPLRDRLLALWDEYERGETAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA
Download Length: 579 bp
>T178107 NZ_CP083853:c1589509-1589036 [Enterobacter roggenkampii]
ATGATTTTTTATCGTCTGGTGACAGGACGCTATGCCAGCGAGGCGTGGAGTGGGAGTGGTGCAAATCAGTATGGCGGACG
TTGGAATCATAAAGGCCATCCAGCTGTGTATGTCTCCACCTCCATCTCGCTGGCCTCACTGGAGATTTTGGTACATGTCA
GAAAAGATACCGTGCTGAATCAGTACCAGCTTTTCAGCATTGATATCCCGGATGACCAGATAGATTACCTGGATAAAGCG
TGGCTCCCCGAGGACTGGCAGGAAAATCCGGCGCCGGTATCGACAATGGATCTGGGAACCGGTTGGTTGCAGGCTAACAG
TGCCCTCGCGCTTATCTTACCTTCCTGTATCATTCCTTATGAAAACAATGCCATCCTTAACCCCTTACATCCGGCGTTCC
ACTCGGCGCTCAATTCAGTTCAGCAACTCCCCTTTATTTTTGATACCCGCCTGGCTGAAAAAACCGCACCCTGA
ATGATTTTTTATCGTCTGGTGACAGGACGCTATGCCAGCGAGGCGTGGAGTGGGAGTGGTGCAAATCAGTATGGCGGACG
TTGGAATCATAAAGGCCATCCAGCTGTGTATGTCTCCACCTCCATCTCGCTGGCCTCACTGGAGATTTTGGTACATGTCA
GAAAAGATACCGTGCTGAATCAGTACCAGCTTTTCAGCATTGATATCCCGGATGACCAGATAGATTACCTGGATAAAGCG
TGGCTCCCCGAGGACTGGCAGGAAAATCCGGCGCCGGTATCGACAATGGATCTGGGAACCGGTTGGTTGCAGGCTAACAG
TGCCCTCGCGCTTATCTTACCTTCCTGTATCATTCCTTATGAAAACAATGCCATCCTTAACCCCTTACATCCGGCGTTCC
ACTCGGCGCTCAATTCAGTTCAGCAACTCCCCTTTATTTTTGATACCCGCCTGGCTGAAAAAACCGCACCCTGA
Antitoxin
Download Length: 185 a.a. Molecular weight: 20470.63 Da Isoelectric Point: 8.1590
>AT178107 WP_003132728.1 NZ_CP063390:3615244-3615798 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLESAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLESAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL
Download Length: 555 bp
>AT178107 NZ_CP083853:c1589949-1589506 [Enterobacter roggenkampii]
ATGAGAACATGGATCCCCGCACAGAAACCTGCTGATAACGCACTTTGGCGTTACGCCGGTTTACCCGCCAACCGAGGTAT
GCGGTTGATTGAATTTCTCAATCAGGGATTACCCGTCAGCGTGCTCGACAACATCCACGAGTGGACGTCCATGTCGAAAG
CGGACATTTTGCGTGTCACGGGTATCAACGAACGTAACGTGGCCCGCCGCAAAAGCGCGGGACGGACGTTAACGCCCGAC
GAGAGCGAACGCGTGGCCCGTTTCGTTCGGGTGCTGGACGCTGCCGTTGACTATTTTGGCAGTAAAGAAGAAGCATGGAC
CTGGCTGCAGGCACCGGTGCGCGGACTCGGGAACGTGGCGCCTGTCGACTTAATAGCGACGGAAACCGGTGCGCTGGAAG
TCACCGATTTAATTGGCCGCCTGGAACACGGCGTGTTCGCATGA
ATGAGAACATGGATCCCCGCACAGAAACCTGCTGATAACGCACTTTGGCGTTACGCCGGTTTACCCGCCAACCGAGGTAT
GCGGTTGATTGAATTTCTCAATCAGGGATTACCCGTCAGCGTGCTCGACAACATCCACGAGTGGACGTCCATGTCGAAAG
CGGACATTTTGCGTGTCACGGGTATCAACGAACGTAACGTGGCCCGCCGCAAAAGCGCGGGACGGACGTTAACGCCCGAC
GAGAGCGAACGCGTGGCCCGTTTCGTTCGGGTGCTGGACGCTGCCGTTGACTATTTTGGCAGTAAAGAAGAAGCATGGAC
CTGGCTGCAGGCACCGGTGCGCGGACTCGGGAACGTGGCGCCTGTCGACTTAATAGCGACGGAAACCGGTGCGCTGGAAG
TCACCGATTTAATTGGCCGCCTGGAACACGGCGTGTTCGCATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|