Detailed information of TA system TA178102

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Xre(antitoxin)
• Location: 4635491..4636749
• Replicon: chromosome
• Accession: NZ_CP063389
• Organism: Pseudomonas aeruginosa strain ST1076_d97burn2

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: IPV45_RS21555
• Protein ID: WP_058199516.1
• Coordinates: 4635491..4636246 (-)
• Length: 252 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: V6AJU7
• Locus tag: IPV45_RS21560
• Protein ID: WP_003086329.1
• Coordinates: 4636381..4636749 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IPV45_RS21545 (IPV45_21540)	4630662..4633205	+	2544	WP_003140632.1	acyl-homoserine-lactone acylase QuiP	-
IPV45_RS21550 (IPV45_21545)	4633360..4634721	-	1362	WP_073647918.1	DNA recombination protein RmuC	-
IPV45_RS21555 (IPV45_21550)	4635491..4636246	-	756	WP_058199516.1	RES family NAD+ phosphorylase	Toxin
IPV45_RS21560 (IPV45_21555)	4636381..4636749	-	369	WP_003086329.1	DUF2384 domain-containing protein	Antitoxin
IPV45_RS21565 (IPV45_21560)	4636819..4638105	-	1287	WP_033994983.1	FAD-binding oxidoreductase	-
IPV45_RS21570 (IPV45_21565)	4638161..4639654	-	1494	WP_033994982.1	aldehyde dehydrogenase family protein	-
IPV45_RS21575 (IPV45_21570)	4639828..4640304	+	477	WP_033994996.1	elongation factor GreAB	-
IPV45_RS21580 (IPV45_21575)	4640307..4640582	-	276	WP_023088486.1	zinc ribbon domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (63-207)

Antitoxin

• Cro/C1-type helix-turn-helix domain (23-47)

Sequences

Toxin

Protein

• Length: 252 a.a.
• Molecular weight: 28270.36 Da
• Isoelectric Point: 7.7294

>T178102 WP_058199516.1 NZ_CP063389:c4636246-4635491 [Pseudomonas aeruginosa]
VSEIWRQCKGERHVRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELFESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Nucleotide

• Length: 756 bp

>T178102 NZ_CP083853:c261051-260764 [Enterobacter roggenkampii]
ATGCATAAATTAACACCTTACGATCCCGCCAACGCGTTGGTGGATGACGAGGAAATCGCCGTGTTTATCGCTGATGCACT
AGAAACAGGCGACTCGACATATATCGCTAAAGCCCTTGGTGTTGTCGCGCGAGCCAAAGGCATGTCGAACATTTCACAGC
AAACCGGTTTATCACGTGAGCAGCTTTATCGGTCATTCAGTGATAAAGGAAACCCAACGCTCAAAACCACGCTCGCGGTC
ATGAAAGCATTGGGTTTTGGGCTAACGCTCAAACACGCCGGGGATTAA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13367.63 Da
• Isoelectric Point: 9.9874

>AT178102 WP_003086329.1 NZ_CP063389:c4636749-4636381 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Nucleotide

• Length: 369 bp

>AT178102 NZ_CP083853:c261360-261058 [Enterobacter roggenkampii]
ATGAAGGAGATTGTTCAGACAGAATCCTTCCGACGCTGGGAGCAAAACTTAAAAGATCGACGAGCGAAGACCATTATCGC
TTCCCGCCTCTTTCGGTTGGCAAATGGCTTAGCGGGCGACGTTAAACCCGTGGGAGAAGGTATAAGTGAGCTAAGGATCC
ACTTTGGTCCGGGCTACAGGATCTATTTTAAAGACCAGGGCAATTACATCATCGTGCTGTTATGTGGTGGTGACAAAAGC
AGCCAGGCCAGAGACATACTGATGGCAAAAATGCTGAGCAATGTATCCCAATGGCAGGAGTGA

Structures

Antitoxin

• AlphaFold DB: V6AJU7