Detailed information of TA system TA178096

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Xre(antitoxin)
• Location: 4635477..4636735
• Replicon: chromosome
• Accession: NZ_CP063388
• Organism: Pseudomonas aeruginosa strain ST1076_d100blood1

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: IPV46_RS21555
• Protein ID: WP_058199516.1
• Coordinates: 4635477..4636232 (-)
• Length: 252 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: V6AJU7
• Locus tag: IPV46_RS21560
• Protein ID: WP_003086329.1
• Coordinates: 4636367..4636735 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IPV46_RS21545 (IPV46_21540)	4630648..4633191	+	2544	WP_003140632.1	acyl-homoserine-lactone acylase QuiP	-
IPV46_RS21550 (IPV46_21545)	4633346..4634707	-	1362	WP_073647918.1	DNA recombination protein RmuC	-
IPV46_RS21555 (IPV46_21550)	4635477..4636232	-	756	WP_058199516.1	RES family NAD+ phosphorylase	Toxin
IPV46_RS21560 (IPV46_21555)	4636367..4636735	-	369	WP_003086329.1	DUF2384 domain-containing protein	Antitoxin
IPV46_RS21565 (IPV46_21560)	4636805..4638091	-	1287	WP_033994983.1	FAD-binding oxidoreductase	-
IPV46_RS21570 (IPV46_21565)	4638147..4639640	-	1494	WP_033994982.1	aldehyde dehydrogenase family protein	-
IPV46_RS21575 (IPV46_21570)	4639814..4640290	+	477	WP_033994996.1	elongation factor GreAB	-
IPV46_RS21580 (IPV46_21575)	4640293..4640568	-	276	WP_023088486.1	zinc ribbon domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (63-207)

Antitoxin

• Cro/C1-type helix-turn-helix domain (23-47)

Sequences

Toxin

Protein

• Length: 252 a.a.
• Molecular weight: 28270.36 Da
• Isoelectric Point: 7.7294

>T178096 WP_058199516.1 NZ_CP063388:c4636232-4635477 [Pseudomonas aeruginosa]
VSEIWRQCKGERHVRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELFESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Nucleotide

• Length: 756 bp

>T178096 NZ_CP083849:3274729-3275100 [Enterobacter hormaechei subsp. steigerwaltii]
ATGGAGCACATGGCAGTGTTTGATACCAATATTCTCATTGATCTCTTCAACAACCGTATTGAAGCTGCGGATGCGATTGA
GCATACCGCGTCGCATCGTGCCATCAGCTTAATTACCTGGATGGAAGTAATGGTGAGCGCTCGCAGGCATGGTCATGAAG
CGAAAACGGCAGCCGTTATGGGCGCTTTTGAAATTATTGATGTGTCTCGGGATATTGCGGAAAGAAGCGTTTTACTACGT
GAGAAGCATGGAATGAAACTGCCTGATGCTATCATTCTGGCCACAGCGCAGAGCAGAAAATGTCCGTTGATTTCTCGCAA
CACGAAAGATTTTGCGGGTATTGACGAGGTCCTTACGCCTTACCAGGTGTAG

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13367.63 Da
• Isoelectric Point: 9.9874

>AT178096 WP_003086329.1 NZ_CP063388:c4636735-4636367 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Nucleotide

• Length: 369 bp

>AT178096 NZ_CP083849:3274484-3274726 [Enterobacter hormaechei subsp. steigerwaltii]
ATGAGCGTTTTGGCGGAACTTGATATGGGCAGAATACTTATCGATTTGTCTGATGACGTGATTCAACGTTTGGATAATCT
CAAGCAATTGCGAAATCAACCACGTGCTGAACTGCTTCGGGAAGCGATAGAGCTGTATCTCGACCAGCAGAGTTCTTCTG
TTATCCGAAATGCGCTTGGTCTGTGGGGAGACAGAAAAGAGGACGGGCTTGAGTATGAACGCAAGCTGCGTGAGGAGTGG
TAA

Structures

Antitoxin

• AlphaFold DB: V6AJU7