178094

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Acetyltransf_4(toxin)
Location 1890634..1892142 Replicon chromosome
Accession NZ_CP063388
Organism Pseudomonas aeruginosa strain ST1076_d100blood1

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag IPV46_RS08790 Protein ID WP_023443480.1
Coordinates 1890634..1891221 (+) Length 196 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag IPV46_RS08795 Protein ID WP_031685565.1
Coordinates 1891288..1892142 (+) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IPV46_RS08785 (IPV46_08785) 1886889..1890368 - 3480 WP_003117605.1 PAS domain-containing hybrid sensor histidine kinase/response regulator -
IPV46_RS08790 (IPV46_08790) 1890634..1891221 + 588 WP_023443480.1 GNAT family protein Toxin
IPV46_RS08795 (IPV46_08795) 1891288..1892142 + 855 WP_031685565.1 AraC family transcriptional regulator Antitoxin
IPV46_RS08800 (IPV46_08800) 1892239..1894404 + 2166 WP_003091606.1 TonB-dependent receptor family protein -
IPV46_RS08805 (IPV46_08805) 1894579..1896453 + 1875 WP_003091605.1 MFS transporter -
IPV46_RS08810 (IPV46_08810) 1896514..1896723 - 210 WP_003091604.1 cold-shock protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(20-152)

Antitoxin

AraC-type arabinose-binding/dimerisation domain

(19-151)


Sequences

Toxin        


Download         Length: 196 a.a.        Molecular weight: 21931.26 Da        Isoelectric Point: 9.8676

>T178094 WP_023443480.1 NZ_CP063388:1890634-1891221 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRTLPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAALEASFTG

Download         Length: 588 bp

>T178094 NZ_CP083849:1990595-1990813 [Enterobacter hormaechei subsp. steigerwaltii]
ATGTCTGATAAACCATTAACAAAAGTCGATTATTTGATGCGCCTGCGACGCTGCCAGTCAATTGACACCCTTGAACGAGT
TATTGAGAAAAATAAATACGAGCTGTCTGATAATGAACTGGCGGTATTTTATTCAGCTGCCGACCATCGTCTTGCTGAGC
TGACCATGAATAAACTGTATGACAAGATCCCCTCTTCGGTGTGGAAATTTGTTCGTTAA

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31819.13 Da        Isoelectric Point: 7.8141

>AT178094 WP_031685565.1 NZ_CP063388:1891288-1892142 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVHLHRLLAEHAGSLETQTRWRETVLALFRRH
ARLPEAPKAGQEPLAVARARELLAARLLAPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACARSSLTTYE

Download         Length: 855 bp

>AT178094 NZ_CP083849:1990193-1990567 [Enterobacter hormaechei subsp. steigerwaltii]
ATGGACGAGTACTCGCCAAAAAGGCATGATATCGCGCAGTTGAAATTTCTCTGCGAATCCTTGTACCATGACTGCCTTGC
CAATCTTGAAGAAAGTAACCATGGCTGGGTGAACGATCCAACGTCTGCTATCAATTTACAGCTTAACGAGCTGATCGAGC
ATATCGCCACCTTCGCACTTAATTATAAAATTAAGTACAATGAAGATAATAAGTTGATAGAGCAAATTGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTACGGCATTAACGCACAGGATTTGCAGAAATGGCGTAAATCAGGAAACCGTCT
ATTTCGCTGCTTCACTAATGTCAGCAGAGCTAATCCGGTTAGTCTTTCCTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References