Detailed information of TA system TA178084

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Xre(antitoxin)
• Location: 4627687..4628945
• Replicon: chromosome
• Accession: NZ_CP063386
• Organism: Pseudomonas aeruginosa strain ST1076_d118limb1

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: IPV48_RS21535
• Protein ID: WP_058199516.1
• Coordinates: 4627687..4628442 (-)
• Length: 252 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: V6AJU7
• Locus tag: IPV48_RS21540
• Protein ID: WP_003086329.1
• Coordinates: 4628577..4628945 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IPV48_RS21525 (IPV48_21515)	4622858..4625401	+	2544	WP_003140632.1	acyl-homoserine-lactone acylase QuiP	-
IPV48_RS21530 (IPV48_21520)	4625556..4626917	-	1362	WP_073647918.1	DNA recombination protein RmuC	-
IPV48_RS21535 (IPV48_21525)	4627687..4628442	-	756	WP_058199516.1	RES family NAD+ phosphorylase	Toxin
IPV48_RS21540 (IPV48_21530)	4628577..4628945	-	369	WP_003086329.1	DUF2384 domain-containing protein	Antitoxin
IPV48_RS21545 (IPV48_21535)	4629015..4630301	-	1287	WP_033994983.1	FAD-binding oxidoreductase	-
IPV48_RS21550 (IPV48_21540)	4630357..4631850	-	1494	WP_033994982.1	aldehyde dehydrogenase family protein	-
IPV48_RS21555 (IPV48_21545)	4632024..4632500	+	477	WP_033994996.1	elongation factor GreAB	-
IPV48_RS21560 (IPV48_21550)	4632503..4632778	-	276	WP_023088486.1	zinc ribbon domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (63-207)

Antitoxin

• Cro/C1-type helix-turn-helix domain (23-47)

Sequences

Toxin

Protein

• Length: 252 a.a.
• Molecular weight: 28270.36 Da
• Isoelectric Point: 7.7294

>T178084 WP_058199516.1 NZ_CP063386:c4628442-4627687 [Pseudomonas aeruginosa]
VSEIWRQCKGERHVRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELFESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Nucleotide

• Length: 756 bp

>T178084 NZ_CP083842:c2758348-2758245 [Enterobacter asburiae]
GGCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13367.63 Da
• Isoelectric Point: 9.9874

>AT178084 WP_003086329.1 NZ_CP063386:c4628945-4628577 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Nucleotide

• Length: 369 bp

>AT178084 NZ_CP083842:2758243-2758383 [Enterobacter asburiae]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAGTCGCCTTGCCTTTTAAGAATAGATGACGACGCCAGGTTTTCCAGT

Structures

Antitoxin

• AlphaFold DB: V6AJU7