Detailed information of TA system TA178078

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Xre(antitoxin)
• Location: 4635480..4636738
• Replicon: chromosome
• Accession: NZ_CP063385
• Organism: Pseudomonas aeruginosa strain St1076_d123blood

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: IPV49_RS21555
• Protein ID: WP_058199516.1
• Coordinates: 4635480..4636235 (-)
• Length: 252 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: V6AJU7
• Locus tag: IPV49_RS21560
• Protein ID: WP_003086329.1
• Coordinates: 4636370..4636738 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IPV49_RS21545 (IPV49_21540)	4630651..4633194	+	2544	WP_003140632.1	acyl-homoserine-lactone acylase QuiP	-
IPV49_RS21550 (IPV49_21545)	4633349..4634710	-	1362	WP_073647918.1	DNA recombination protein RmuC	-
IPV49_RS21555 (IPV49_21550)	4635480..4636235	-	756	WP_058199516.1	RES family NAD+ phosphorylase	Toxin
IPV49_RS21560 (IPV49_21555)	4636370..4636738	-	369	WP_003086329.1	DUF2384 domain-containing protein	Antitoxin
IPV49_RS21565 (IPV49_21560)	4636808..4638094	-	1287	WP_033994983.1	FAD-binding oxidoreductase	-
IPV49_RS21570 (IPV49_21565)	4638150..4639643	-	1494	WP_033994982.1	aldehyde dehydrogenase family protein	-
IPV49_RS21575 (IPV49_21570)	4639817..4640293	+	477	WP_033994996.1	elongation factor GreAB	-
IPV49_RS21580 (IPV49_21575)	4640296..4640571	-	276	WP_023088486.1	zinc ribbon domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (63-207)

Antitoxin

• Cro/C1-type helix-turn-helix domain (23-47)

Sequences

Toxin

Protein

• Length: 252 a.a.
• Molecular weight: 28270.36 Da
• Isoelectric Point: 7.7294

>T178078 WP_058199516.1 NZ_CP063385:c4636235-4635480 [Pseudomonas aeruginosa]
VSEIWRQCKGERHVRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELFESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Nucleotide

• Length: 756 bp

>T178078 NZ_CP083835:c148856-148479 [Enterobacter asburiae]
ATGCAAACACAACCTGTTCCCCCGACACAGGAGGCTTCACCACGCCCGTCACCAGTGGAGATCTGGCTCCGCCTTTTGAG
TCACCTGCTGGACCGTCACTACGGTCTGACGTTAAACGACACGCCATTTTGCAATGATGGTGTGATCCAGGAGCATATCG
ACGCCGGTATCTCACTGTGCGACGCGGTGAATTTTATCGTGGAGAAATACGCCCTGATACGCACCGATCGTCACGGTTTC
AGCGCAGAAACACAGTCCCCACTCATCAGCAGTATTGATATCCTTCGCGCCCGTAAGGCCTGTGGACTGATGGCACGCAA
TGGCTACAGACTGGTGACCGATATCACCACCGGCAAATACAGCGAGGTGACTCGATGA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13367.63 Da
• Isoelectric Point: 9.9874

>AT178078 WP_003086329.1 NZ_CP063385:c4636738-4636370 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Nucleotide

• Length: 369 bp

>AT178078 NZ_CP083835:c149265-148906 [Enterobacter asburiae]
TTGTCGAATAAAATACCGCCTGTAAACCACAATATCGCCGAACCCTGGTGGGGGCTTAAACGCGATATCACACCCTGTTT
TGGCGCTCGCCTGGTGCAGGAGGGCAACCGGCTGCACTATCTCGCCGACCGCGCCAGTATCACCGGGCAGTTCAGCGACG
CGGATTTACGCCATCTGGACCAGGCATTTCCGCTGCTGCTCAAACAGCTTGAACTGATGCTCACCAGCGGTGAACTCAAT
CCCCGCCATCAGCACGGCGTCACGCTCTACGCAAAAGGGCTGACCTGCAACGCGGATACACTCGGCAGTTGCGGATATGT
CTATATAGCGATTTACCCGACACCTGCAACAACAGAATAA

Structures

Antitoxin

• AlphaFold DB: V6AJU7