Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3845594..3846219 Replicon chromosome
Accession NZ_CP063380
Organism Pectobacterium versatile strain ECC15

Toxin (Protein)


Gene name Hha Uniprot ID C6DB72
Locus tag IMY97_RS17610 Protein ID WP_005976087.1
Coordinates 3846016..3846219 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID C6DB73
Locus tag IMY97_RS17605 Protein ID WP_005976089.1
Coordinates 3845594..3845962 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IMY97_RS17590 (IMY97_17725) 3841222..3844350 + 3129 WP_103862997.1 efflux RND transporter permease subunit -
IMY97_RS17595 (IMY97_17730) 3844587..3844835 + 249 WP_039506474.1 type B 50S ribosomal protein L31 -
IMY97_RS17600 (IMY97_17735) 3844852..3844995 + 144 WP_005976091.1 type B 50S ribosomal protein L36 -
IMY97_RS17605 (IMY97_17740) 3845594..3845962 + 369 WP_005976089.1 Hha toxicity modulator TomB Antitoxin
IMY97_RS17610 (IMY97_17745) 3846016..3846219 + 204 WP_005976087.1 HHA domain-containing protein Toxin
IMY97_RS17620 (IMY97_17755) 3846962..3847282 + 321 WP_103862996.1 MGMT family protein -
IMY97_RS17625 (IMY97_17760) 3847302..3847883 - 582 WP_039490514.1 YbaY family lipoprotein -
IMY97_RS17630 (IMY97_17765) 3848096..3848959 + 864 WP_130622068.1 acyl-CoA thioesterase II -
IMY97_RS17635 (IMY97_17770) 3849094..3850380 - 1287 WP_161973278.1 ammonium transporter AmtB -
IMY97_RS17640 (IMY97_17775) 3850420..3850758 - 339 WP_002208627.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8145.52 Da        Isoelectric Point: 8.9008

>T178067 WP_005976087.1 NZ_CP063380:3846016-3846219 [Pectobacterium versatile]
MKKIDYLMRLRKCTTIDTLERVIEKNKYELSNDELEMFFSAADHRLAELTMNKLYDKVPTAVWRYVR

Download         Length: 204 bp

>T178067 NZ_CP083834:521694-521978 [Enterobacter asburiae]
ATGATTTATGAACTGGCATTTGACCCGAGGGCGTTAAAGGAGTGGAGCAAGCTGGGGCAGACTGTAAAAGACCAGTTTAA
GAAGAAACTTGCGGACGTGCTGGTGAGCCCCAGGGTCGAATCGGCCCGCCTGCATGGTCTGCCGGATTGCTACAAAATAA
AACTCAGATCGCAGGGTTATCGTTTGGTCTATCAGGTTCAGGACAACGTTGTAACGGTATTTGTTATCGCTATCGGTAAG
CGAGAGAAATCAGCCGTTTATCATGATGCAAACAAACGGCTTTAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14032.77 Da        Isoelectric Point: 4.4787

>AT178067 WP_005976089.1 NZ_CP063380:3845594-3845962 [Pectobacterium versatile]
MDEYTPKHYDIAQLRFLCENLCDESIATLGDSSHGWVNDPTSAINLQLNELIEHIATFILTFKIKYPNESELSEQVEKYL
DDTYVLFSNYGINDAELRRWQKSKAKLFGMFSGENVCTPAKT

Download         Length: 369 bp

>AT178067 NZ_CP083834:521462-521704 [Enterobacter asburiae]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAACGAGGCTTATGCCGTGCTGGAAAAACTCAATATCACCCC
AACGGAAGCCGTGCGATTACTGTTTCAGTACGTCGCGGAGACGGGACGTATGCCGGTGAAAACGGTCACGATTAGCGACA
GCGAAGATGCGCTGATACAGACGGTCCGGGAGCGACTGGCGAATCCGCAAAAGGGAATCAAGGTTAGTCTGGATGATTTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1D7Z3F0

Antitoxin

Source ID Structure
AlphaFold DB A0A1D7Z3G5

References