Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 3808212..3808848 Replicon chromosome
Accession NZ_CP063380
Organism Pectobacterium versatile strain ECC15

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag IMY97_RS17450 Protein ID WP_103941744.1
Coordinates 3808666..3808848 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag IMY97_RS17445 Protein ID WP_107332493.1
Coordinates 3808212..3808643 (-) Length 144 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IMY97_RS17425 (IMY97_17560) 3803466..3804380 + 915 WP_107332497.1 SPFH domain-containing protein -
IMY97_RS17430 (IMY97_17565) 3804380..3804835 + 456 WP_180744068.1 NfeD family protein -
IMY97_RS17435 (IMY97_17570) 3804871..3805278 - 408 WP_180744067.1 Cu(I)-responsive transcriptional regulator -
IMY97_RS17440 (IMY97_17575) 3805395..3808118 + 2724 WP_188246788.1 copper-exporting P-type ATPase CopA -
IMY97_RS17445 (IMY97_17580) 3808212..3808643 - 432 WP_107332493.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
IMY97_RS17450 (IMY97_17585) 3808666..3808848 - 183 WP_103941744.1 type II toxin-antitoxin system HicA family toxin Toxin
IMY97_RS17455 (IMY97_17590) 3809024..3809842 + 819 WP_103941746.1 TraB/GumN family protein -
IMY97_RS17460 (IMY97_17595) 3809913..3810392 + 480 WP_005976136.1 Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase YbaK -
IMY97_RS17465 (IMY97_17600) 3810626..3812008 - 1383 WP_103941748.1 glycosyl hydrolase family 28 protein -
IMY97_RS17470 (IMY97_17605) 3812274..3813260 - 987 WP_188246787.1 GTPase -
IMY97_RS17475 (IMY97_17610) 3813277..3813480 - 204 WP_005976130.1 YbdD/YjiX family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-60)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(6-138)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6512.68 Da        Isoelectric Point: 10.3299

>T178066 WP_103941744.1 NZ_CP063380:c3808848-3808666 [Pectobacterium versatile]
MTSTDLIKELAAAGCECKRHNGGSHQIWWSPITGKTFPVPHPKKDLPLGTVKSIKKMAGI

Download         Length: 183 bp

>T178066 NZ_CP083834:c271841-271539 [Enterobacter asburiae]
ATGAAGGAGATCGTTCAGACAGAATCCTTCCAACGCTGGGAGCAAAACTTAAAAGATCGGCGAGCGAAAACCATTATCGC
TTCCCGCCTCTTTCGGTTGGCAAATGGTTTAGCGGGCGACATTAAACCCGTGGGCGAAGGTATAAGTGAGCTGAGGATCC
ACTATGGTCCGGGCTACAGAATCTATTTTAAAGACCAGGGCAATTGCATCATCGTGCTGTTGTGTGGTGGTGACAAAAGC
AGCCAGGCCAGAGACATACTTATGGCAAAAATGCTGAGCAATGTATCCCAATGGCAGGAGTGA

Antitoxin


Download         Length: 144 a.a.        Molecular weight: 16036.95 Da        Isoelectric Point: 4.3145

>AT178066 WP_107332493.1 NZ_CP063380:c3808643-3808212 [Pectobacterium versatile]
MFFSVGVETPKDDATAYGLIVPALCTDDYGCFSAADSQQEIARMAREAILTLIDEAVSRGNLDIKRLNDAGHLIYAAIPD
FADYDSWFVLDVDLSAFEGKPQRLNISLPDTLIQRIDNRVREQPGTYRDRSHFLAEAARHELE

Download         Length: 432 bp

>AT178066 NZ_CP083834:c271532-271245 [Enterobacter asburiae]
ATGCATAAATTAACACCCTACGATCCAGCCAATGCGCTGGTGGATGACGAGGAAATCGCCGTGTTTATGGCTGATGCCTT
AGAAACGGGCGACTCAGCGTATATTGCTAAAGCGCTGGGCGTCATCGCGCGCGCGAAAGGAATGTCGACCATTTCACAGC
AAACTGGCCTATCACGAGAGCAACTGTATCGATCGTTCAGTGATAAAGGAAACCCAACGCTTAAAACCACTCTGGCGGTC
ATGAAAGCATTGGGTCTTGGGCTAACAATCAAACACGCTGGAGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References