Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 984639..985189 Replicon chromosome
Accession NZ_CP063380
Organism Pectobacterium versatile strain ECC15

Toxin (Protein)


Gene name ccdB Uniprot ID A0A3R8NCD5
Locus tag IMY97_RS04475 Protein ID WP_039483443.1
Coordinates 984639..984947 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID A0A3R8NHE1
Locus tag IMY97_RS04480 Protein ID WP_052012050.1
Coordinates 984950..985189 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IMY97_RS04455 (IMY97_04420) 979804..981411 - 1608 WP_103971083.1 thiamine/thiamine pyrophosphate ABC transporter permease ThiP -
IMY97_RS04460 (IMY97_04425) 981387..982367 - 981 WP_145963920.1 thiamine ABC transporter substrate binding subunit -
IMY97_RS04465 (IMY97_04430) 982585..984243 - 1659 WP_188246674.1 HTH-type transcriptional regulator SgrR -
IMY97_RS04470 (IMY97_04435) 984334..984498 + 165 WP_039483441.1 glucose uptake inhibitor SgrT -
IMY97_RS04475 (IMY97_04440) 984639..984947 - 309 WP_039483443.1 CcdB family protein Toxin
IMY97_RS04480 (IMY97_04445) 984950..985189 - 240 WP_052012050.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
IMY97_RS04485 (IMY97_04450) 985881..987500 + 1620 WP_103942236.1 methyl-accepting chemotaxis protein -
IMY97_RS04490 (IMY97_04455) 987726..988562 + 837 WP_103861883.1 AraC family transcriptional regulator -
IMY97_RS04495 (IMY97_04460) 988668..989402 + 735 WP_103861882.1 AzlC family ABC transporter permease -
IMY97_RS04500 (IMY97_04465) 989399..989710 + 312 WP_103861881.1 AzlD domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(9-79)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11785.63 Da        Isoelectric Point: 9.3363

>T178065 WP_039483443.1 NZ_CP063380:c984947-984639 [Pectobacterium versatile]
MQYKVYRNNGNSNSYPYLLNIQSDIIGELHTRLVIPLFPLHKIARPPARRLTPIVTVEGNDYLIMTHEMASVRRSQLGHE
VMDAQVYRKTIKDAVDFLLDGF

Download         Length: 309 bp

>T178065 NZ_CP083834:c271532-271245 [Enterobacter asburiae]
ATGCATAAATTAACACCCTACGATCCAGCCAATGCGCTGGTGGATGACGAGGAAATCGCCGTGTTTATGGCTGATGCCTT
AGAAACGGGCGACTCAGCGTATATTGCTAAAGCGCTGGGCGTCATCGCGCGCGCGAAAGGAATGTCGACCATTTCACAGC
AAACTGGCCTATCACGAGAGCAACTGTATCGATCGTTCAGTGATAAAGGAAACCCAACGCTTAAAACCACTCTGGCGGTC
ATGAAAGCATTGGGTCTTGGGCTAACAATCAAACACGCTGGAGATTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9022.34 Da        Isoelectric Point: 10.0137

>AT178065 WP_052012050.1 NZ_CP063380:c985189-984950 [Pectobacterium versatile]
MPVTSVRHKKTVSVTLEPVLLQQAREAGINLSAILTEALKREIRLSEGEKWKQQNQKALQELNRITDKHGLLSDDDRTF

Download         Length: 240 bp

>AT178065 NZ_CP083834:c271841-271539 [Enterobacter asburiae]
ATGAAGGAGATCGTTCAGACAGAATCCTTCCAACGCTGGGAGCAAAACTTAAAAGATCGGCGAGCGAAAACCATTATCGC
TTCCCGCCTCTTTCGGTTGGCAAATGGTTTAGCGGGCGACATTAAACCCGTGGGCGAAGGTATAAGTGAGCTGAGGATCC
ACTATGGTCCGGGCTACAGAATCTATTTTAAAGACCAGGGCAATTGCATCATCGTGCTGTTGTGTGGTGGTGACAAAAGC
AGCCAGGCCAGAGACATACTTATGGCAAAAATGCTGAGCAATGTATCCCAATGGCAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3R8NCD5

Antitoxin

Source ID Structure
AlphaFold DB A0A3R8NHE1

References