Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 211923..213508 Replicon chromosome
Accession NZ_CP063380
Organism Pectobacterium versatile strain ECC15

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag IMY97_RS00955 Protein ID WP_188246651.1
Coordinates 211923..213242 (-) Length 440 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag IMY97_RS00960 Protein ID WP_010302402.1
Coordinates 213242..213508 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IMY97_RS00930 (IMY97_00865) 207896..208036 + 141 WP_005976668.1 50S ribosomal protein L34 -
IMY97_RS00935 (IMY97_00870) 208055..208414 + 360 WP_010302382.1 ribonuclease P protein component -
IMY97_RS00940 (IMY97_00875) 208378..208635 + 258 WP_010302384.1 membrane protein insertion efficiency factor YidD -
IMY97_RS00945 (IMY97_00880) 208638..210272 + 1635 WP_039485128.1 membrane protein insertase YidC -
IMY97_RS00950 (IMY97_00885) 210402..211766 + 1365 WP_103862404.1 tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE -
IMY97_RS00955 (IMY97_00890) 211923..213242 - 1320 WP_188246651.1 type II toxin-antitoxin system HipA family toxin Toxin
IMY97_RS00960 (IMY97_00895) 213242..213508 - 267 WP_010302402.1 helix-turn-helix domain-containing protein Antitoxin
IMY97_RS00965 (IMY97_00900) 213669..214235 + 567 WP_103862406.1 hypothetical protein -
IMY97_RS00970 (IMY97_22405) 214387..214911 + 525 WP_242934911.1 hypothetical protein -
IMY97_RS22135 214949..215293 + 345 WP_278312354.1 HNH endonuclease signature motif containing protein -
IMY97_RS00980 (IMY97_00915) 215357..216208 - 852 WP_040032822.1 SDR family oxidoreductase -
IMY97_RS00985 (IMY97_00920) 216323..216760 + 438 WP_188246652.1 helix-turn-helix domain-containing protein -
IMY97_RS00990 (IMY97_00925) 216775..217326 - 552 WP_109225828.1 TetR/AcrR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(150-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 440 a.a.        Molecular weight: 49223.34 Da        Isoelectric Point: 6.5030

>T178060 WP_188246651.1 NZ_CP063380:c213242-211923 [Pectobacterium versatile]
MAALDVYMNGYRVGILTKTGSGAHHFSYDANWLGLPGSRPISLSMPLRHQSYQGDEVYNFFDNLLPDNPDIRRRIVARHH
ADSTQPFDLLDKVGKDSVGALQIVPQGTPVHDIKKIEYKTLSEQQLENILAGYLSDAPLGMIDTEDDFRISIAGAQEKTA
LLYLDDHWCLPFSTTPTTHIIKLPIGKIESHSYSIDMSDSVENEYLCLLIAKAFGLPVPHCFMINAGKIKALAVERFDRK
YASDVSWIMRLPQEDFCQVLNVPSALKYENHGGPGISAIMSFLLGSVDPERDRYRFMQAQVLFWLLAATDGHAKNFSLFI
ESEGRYRLTPFYDILSMYPAMGGRGIDRREAKLAMGLTGSRGKKYAIEQIFPRHFFQTAKAVGFARESMENILAEFAQTV
ETVMTTVGSQLPVDFPTHISEAILAGLQARSRRLMSGWE

Download         Length: 1320 bp

>T178060 NZ_CP083830:c4798964-4798593 [Enterobacter asburiae]
ATGGAGCACATGGCGGTGTTCGATACCAATATACTCATTGATCTATTTAATAATCGCGTTGAGGCTGCGGATGCAATTGA
TCGCACAGCTTCGCATCGAGCCATTAGCCTGATCACATGGATGGAAGTCATGGTGGGTGCCCGCAAACATGGTCACGAAG
CGAAAACTGCGACAGTGATGGGCGTATTTGAGATTATTGATATCACCCGAGATATCGCTGAAAGAAGTGTAATTCTGCGC
GAGAAGCATGGAATGAAACTGCCTGATGCTATCATTCTGGCCACAGCTCAGAGCAGAAATTGTCCGTTGATTTCTCGAAA
CACGAAAGACTTTTCGGGCATTACTGGAGTCGTTTCACCTTACCAACTATAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9887.16 Da        Isoelectric Point: 9.7281

>AT178060 WP_010302402.1 NZ_CP063380:c213508-213242 [Pectobacterium versatile]
MKVTNSKQLSSYLKDVRITQKLSQGKVASKVGIRQDTVSSFEQHPDSTKLETFFKILSALNLELTVTPRNVDTANNEASV
ASSWKEEW

Download         Length: 267 bp

>AT178060 NZ_CP083830:c4799209-4798967 [Enterobacter asburiae]
ATGAGTCTTTCCGCGGATCTTGATATGGGCAGAATTCTGATCGATTTGTCTGATGACGTAATTCAACGACTGGATAATCT
GAAGCAGCTGCGTAACCGGCCTCGTGCCGAATTGCTTCGGGAAGCCATTGAGCAATATCTCGACCAGCAGAGTTCATCGG
TTATCCGCGATGCGCTTGGCTTGTGGGGAAACCAGCAGGAAGATGGGCTTGAGTATGAACGCAAGCTGCGTGAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References