Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Txe-YefM
Location 2211209..2211741 Replicon chromosome
Accession NZ_CP063373
Organism Streptomyces ferrugineus strain CCTCC AA2014009

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag IM697_RS10075 Protein ID WP_194046718.1
Coordinates 2211481..2211741 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag IM697_RS10070 Protein ID WP_194046716.1
Coordinates 2211209..2211484 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IM697_RS10045 2206566..2207636 + 1071 WP_194046706.1 prenyltransferase -
IM697_RS10050 2207652..2207954 - 303 WP_194046708.1 hypothetical protein -
IM697_RS10055 2208000..2209010 - 1011 WP_194046710.1 LLM class F420-dependent oxidoreductase -
IM697_RS10060 2209113..2209934 - 822 WP_194046712.1 hypothetical protein -
IM697_RS10065 2210099..2211040 - 942 WP_194046714.1 N-acetylmuramoyl-L-alanine amidase -
IM697_RS10070 2211209..2211484 + 276 WP_194046716.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
IM697_RS10075 2211481..2211741 + 261 WP_194046718.1 Txe/YoeB family addiction module toxin Toxin
IM697_RS10080 2212196..2212396 - 201 WP_194046720.1 hypothetical protein -
IM697_RS10085 2212393..2212641 - 249 WP_194046722.1 hypothetical protein -
IM697_RS10090 2212777..2213217 + 441 WP_194049660.1 hypothetical protein -
IM697_RS10095 2213244..2214448 + 1205 Protein_1972 hypothetical protein -
IM697_RS10100 2214727..2215101 - 375 WP_194046724.1 hypothetical protein -
IM697_RS10105 2215857..2216528 - 672 WP_194046726.1 class I SAM-dependent methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-72)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10212.53 Da        Isoelectric Point: 9.3738

>T178058 WP_194046718.1 NZ_CP063373:2211481-2211741 [Streptomyces ferrugineus]
VRSVSFDPDGWEDFLYWLASDRKTARRVTRLIGEIQRTPFEGIGKPEPLKGELSGYWSRRIDDEHRLVYRADDKEVKILK
ARYHYG

Download         Length: 261 bp

>T178058 NZ_CP083830:3754518-3754736 [Enterobacter asburiae]
ATGTCTGATAAACCACTCACAAAAATCGATTATTTGATGCGCTTACGACGTTGTCAGTCAATTGACACGCTCGAGCGCGT
CATTGAAAAGAATAAATACGAGCTTTCTGATAATGAACTGGCGGTATTTTATTCAGCCGCTGACCATCGTCTTGCTGAAC
TGACAATGAATAAGCTGTATGACAAAATCCCTACTTCTGTGTGGAAATTTGTCCGTTAA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 9940.19 Da        Isoelectric Point: 4.8359

>AT178058 WP_194046716.1 NZ_CP063373:2211209-2211484 [Streptomyces ferrugineus]
MSISATEARKTLFPLIERVNTDHTPVRISSKSGDAVLMSADDYDAWQETVYLLRSPANARRLMEAVARDKAGEAGVTKSM
DELRELAGGEA

Download         Length: 276 bp

>AT178058 NZ_CP083830:3754116-3754490 [Enterobacter asburiae]
ATGGACGAGTACTCGCCAAAAAGGCATGATATCGCGCAGTTGAAATTTCTCTGCGAATCCTTGTACCATGACTGCCTTGC
CAATCTTGATGAAAGCAACCATGGCTGGGTAAACGACCCAACGTCTGCCATCAATTTACAGTTGAATGAGCTGATAGAGC
ATATCGCAACCTTCGCACTTAATTATAAAATTAAGTACAATGAAGATAATAAGCTCATTGAGCAAATTGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGTTACGGCATTAACGCTCAGGATTTGCAAAAATGGCGTAAATCGGGAAATCGGCT
ATTCCGCTGTTTCGTCAACGTGAGCAGAGCTAACCCGGTGAGTCTTTCCTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References