Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4393532..4394330 Replicon chromosome
Accession NZ_CP063369
Organism Escherichia coli strain 1409

Toxin (Protein)


Gene name yeeV Uniprot ID U9XMP3
Locus tag FOI11_RS20995 Protein ID WP_000854735.1
Coordinates 4393532..4393909 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A1M1EW42
Locus tag FOI11_RS21000 Protein ID WP_032153712.1
Coordinates 4393956..4394330 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOI11_RS20960 4389095..4390273 + 1179 WP_000094991.1 type II secretion system protein GspL -
FOI11_RS20965 4390275..4390811 + 537 WP_000942785.1 GspM family type II secretion system protein YghD -
FOI11_RS20970 4391226..4391552 - 327 WP_000779483.1 type II toxin-antitoxin system RelE/ParE family toxin -
FOI11_RS20975 4391549..4391812 - 264 WP_025492088.1 type II toxin-antitoxin system ParD family antitoxin -
FOI11_RS20980 4391884..4392750 - 867 WP_032153714.1 DUF4942 domain-containing protein -
FOI11_RS20985 4392835..4393032 - 198 WP_000839265.1 DUF957 domain-containing protein -
FOI11_RS20990 4393044..4393535 - 492 WP_023155722.1 hypothetical protein -
FOI11_RS20995 4393532..4393909 - 378 WP_000854735.1 TA system toxin CbtA family protein Toxin
FOI11_RS21000 4393956..4394330 - 375 WP_032153712.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
FOI11_RS21005 4394410..4394631 - 222 WP_000692345.1 DUF987 domain-containing protein -
FOI11_RS21010 4394700..4395176 - 477 WP_001186715.1 RadC family protein -
FOI11_RS21015 4395192..4395677 - 486 WP_032153711.1 antirestriction protein -
FOI11_RS21020 4395769..4396587 - 819 WP_001234693.1 DUF945 domain-containing protein -
FOI11_RS21025 4396678..4396887 - 210 WP_023155727.1 DUF905 family protein -
FOI11_RS21030 4396917..4397594 - 678 WP_023155728.1 hypothetical protein -
FOI11_RS21035 4397713..4398597 - 885 WP_175098405.1 50S ribosome-binding GTPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4391549..4405713 14164


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14061.07 Da        Isoelectric Point: 8.2904

>T178044 WP_000854735.1 NZ_CP063369:c4393909-4393532 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T178044 NZ_CP083821:c3798503-3798090 [Enterobacter cloacae subsp. cloacae]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCGCAGTGGATGTCGTTATTGCTCCACGGCCTGGTCGCGGC
ATTTGTTTTACTGATGCCGTGGCCGCTTAGCTATACGCCGCTGTGGCTGTTGTTGCTGTCGTTCGTCGTTTTTGACAGCG
TGCGCAGCCAGCGCCGGATCAATGCCCGCCAGGGTGAGATCAAATTACTGATGGACTCCCGCCTGCGCTGGCAGGGCAAA
GAGTGGGATATCCTCGGTATGCCCTGGATGCTCAGTTCCGGCATGATGCTACGGTTACGCCAGGTGGGCGGCGGTAAGTG
CCAGCATCTGTGGCTGGCCGCCGACAGTATGGATATTGCGGAGTGGCGGGAACTGCGCCGGATGCTACTGCAGCAGCAAC
CGACGCAGGAATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13697.51 Da        Isoelectric Point: 6.6240

>AT178044 WP_032153712.1 NZ_CP063369:c4394330-4393956 [Escherichia coli]
VSDTLPGTTHPDDNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYMAVYPTLAPATTS

Download         Length: 375 bp

>AT178044 NZ_CP083821:c3798750-3798484 [Enterobacter cloacae subsp. cloacae]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCATGCCGACGCGGCATGCGTGAACTTGATATCTCCATCATGCCTTT
CTTCGAATATGAGTATGACAGCTTAAGCGATGAGGATAAGCGTCTGTTTGTTCGCCTGCTTGAGTCTGACGATCCCGATT
TATTCAACTGGCTGATGAACCACGGCAAGCCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XMP3

Antitoxin

Source ID Structure
AlphaFold DB A0A1M1EW42

References