Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2316872..2317490 Replicon chromosome
Accession NZ_CP063369
Organism Escherichia coli strain 1409

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag FOI11_RS11160 Protein ID WP_001291435.1
Coordinates 2317272..2317490 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag FOI11_RS11155 Protein ID WP_000344800.1
Coordinates 2316872..2317246 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOI11_RS11145 2311961..2313154 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
FOI11_RS11150 2313177..2316326 + 3150 WP_001132469.1 multidrug efflux RND transporter permease subunit -
FOI11_RS11155 2316872..2317246 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
FOI11_RS11160 2317272..2317490 + 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
FOI11_RS11165 2317662..2318213 + 552 WP_000102564.1 maltose O-acetyltransferase -
FOI11_RS11170 2318329..2318799 + 471 WP_000136192.1 YlaC family protein -
FOI11_RS11175 2318963..2320513 + 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
FOI11_RS11180 2320555..2320908 - 354 WP_000878140.1 DUF1428 domain-containing protein -
FOI11_RS11190 2321287..2321598 + 312 WP_000409911.1 MGMT family protein -
FOI11_RS11195 2321629..2322201 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T178038 WP_001291435.1 NZ_CP063369:2317272-2317490 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T178038 NZ_CP083821:c632369-631848 [Enterobacter cloacae subsp. cloacae]
GTGAATAACATGAAAATAGGGATTTTTTCAGATGACGTTGAGTATGATCTAAGCCATTTCGATTGCGGAGAAGAGAGCCT
AAACACCTTTCTGACGGCACACCTGAAACGCCAGCATCGTGGGAAATTTTTGCGGGGTTACGTTCTTGTCGCATCCGGGG
AAAAGCCGCGGGTGTTGGGTTATTACACGCTGTCCGGGAGCTGCTTTGAAAAGGCGTACCTTCCTTCTAAAACCCAGCAG
AAGCGAGTGCCTTACAAAAATGTTCCCAGCGTCACGCTGGGCCGCCTGGCGATAGATAAACGCTTCCAGGGGCAAGGATT
GGGGGAGTTGCTGGTCACCCATGCTCTGAAAACGGTCTACCTGGCGTCTTTTGCCGTGGGTATCCACGGGATATTCGTAG
AAGCGCTGAACGACAGCGCCAAAAACTTTTACCTTAAACTGGGGTTTATCGCCCTTCAGGCAGAGAATGAAAATACTCTC
TTCCTGCCGACTAAAACCATTGAAAGACTGTTTGCAGATTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT178038 WP_000344800.1 NZ_CP063369:2316872-2317246 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT178038 NZ_CP083821:c632642-632373 [Enterobacter cloacae subsp. cloacae]
ATGTCAGCACTAAAGAAACAGCGTATCGATCTACGCTTAACCGAAGACGACAAAAGCCTGATCGAAGAAGCAGCGGCAAT
GACGAACCAGTCAATTTCACAATTCATGGTAAGTACGGCCTCCGAACGCGCAGCAGAAGTGATTGAACAGCACCGCCGCC
TGATCCTCAACGAGGCATCCTGGAACCAGGTGATGGATGCGATCAGTAACCCGCCAACACCAAATGAACGACTGAAGCGA
GCAGCCAGGCGTCTCCAGGATCTGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References