Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF-MazE
Location 2410906..2411510 Replicon chromosome
Accession NZ_CP063368
Organism Staphylococcus delphini strain 245-1

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag IPU21_RS11385 Protein ID WP_212574782.1
Coordinates 2411172..2411510 (+) Length 113 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag IPU21_RS11380 Protein ID WP_096540352.1
Coordinates 2410906..2411175 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IPU21_RS11355 (IPU21_11370) 2406238..2406843 - 606 WP_212574781.1 DUF2812 domain-containing protein -
IPU21_RS11360 (IPU21_11375) 2406827..2407159 - 333 WP_096540346.1 PadR family transcriptional regulator -
IPU21_RS11365 (IPU21_11380) 2407314..2408855 - 1542 WP_019166288.1 SLC13 family permease -
IPU21_RS11370 (IPU21_11385) 2409436..2409897 - 462 WP_019166289.1 threonine/serine exporter family protein -
IPU21_RS11375 (IPU21_11390) 2409910..2410665 - 756 WP_051005999.1 threonine/serine exporter family protein -
IPU21_RS11380 (IPU21_11395) 2410906..2411175 + 270 WP_096540352.1 AbrB family transcriptional regulator Antitoxin
IPU21_RS11385 (IPU21_11400) 2411172..2411510 + 339 WP_212574782.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
IPU21_RS11390 (IPU21_11405) 2411716..2412471 - 756 WP_212574783.1 heme-dependent peroxidase -
IPU21_RS11395 (IPU21_11410) 2412639..2413628 + 990 WP_212574784.1 phosphate acetyltransferase -
IPU21_RS11400 (IPU21_11415) 2413628..2414464 + 837 WP_212574785.1 lipoate--protein ligase family protein -
IPU21_RS11405 (IPU21_11420) 2415158..2415562 - 405 WP_212574786.1 arsenate reductase (thioredoxin) -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-106)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 13132.26 Da        Isoelectric Point: 9.9095

>T178027 WP_212574782.1 NZ_CP063368:2411172-2411510 [Staphylococcus delphini]
MSIKQFDIIYIDLNPTRGREKQNMRPFLVINNQMMIDGTEFVWVVPITNRELRYPTDIELKTKKGLVSGVIDTIQIRALD
LNARQHHYKDALQDNLKSKVLKAIQTYLNPNY

Download         Length: 339 bp

>T178027 NZ_CP083819:477231-477515 [Enterobacter roggenkampii]
ATGACTTATGAACTGGAATTTGACCCGAGGGCGTTAAAGGAGTGGAGCAAGCTGGGGGATACGGTCAAAAACCAGTTTAA
GAAGAAACTTGCCGGGGTATTGGCAAATCCCCGGGTCGAATCGGCCCGCCTGCATAATCTGCCTGATTGCTACAAAATCA
AACTCAAGGCGTCTGGCTATCGCCTGGTTTATCAGGTTCAGGACAGCGTTATAACGGTATTTGTTATCGCCGTTGGGAAA
AGAGAGAAATCAGCCGCTTATCACGACGCAAATAAACGGCTTTAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9976.15 Da        Isoelectric Point: 4.4501

>AT178027 WP_096540352.1 NZ_CP063368:2410906-2411175 [Staphylococcus delphini]
MTQTFNDVSISTERIFKNGNSQAMSLSKKMIQSVDFEIGDTVEVQKINGGLFITKKEVSIEDSIKNFFQNGGKYQESEVD
FGESVGREI

Download         Length: 270 bp

>AT178027 NZ_CP083819:476999-477241 [Enterobacter roggenkampii]
ATGGCCACGCTAAACGTCCGTCTGGATGACAAACTTAAAAACGAGGCTTATGCCGTGCTGGAAAAACTCAATATTACCCC
AACGGAAGCGGTGCGATTGCTGTTTCAGTACGTTGCTGAAACGGGGCGCATGCCGGTGAAAACGGTCACCATTAGCGACA
GCGAAGATGCGCTGATACAGACAGTCCGGGAGCGACTGGCTAATCCGCAAAAGGGAATAAAGGTTAGTCTGGATGACTTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References