Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 906545..907069 Replicon chromosome
Accession NZ_CP063368
Organism Staphylococcus delphini strain 245-1

Toxin (Protein)


Gene name mazF Uniprot ID A0A2A4EDC7
Locus tag IPU21_RS04085 Protein ID WP_014613379.1
Coordinates 906716..907069 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A166MM16
Locus tag IPU21_RS04080 Protein ID WP_014613378.1
Coordinates 906545..906715 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IPU21_RS04055 (IPU21_04070) 902456..902929 + 474 WP_212575274.1 PH domain-containing protein -
IPU21_RS04060 (IPU21_04075) 902922..904433 + 1512 WP_096606401.1 PH domain-containing protein -
IPU21_RS04065 (IPU21_04080) 904417..904932 + 516 WP_096606399.1 PH domain-containing protein -
IPU21_RS04070 (IPU21_04085) 904929..905279 + 351 WP_212575275.1 holo-ACP synthase -
IPU21_RS04075 (IPU21_04090) 905313..906461 + 1149 WP_212575276.1 alanine racemase -
IPU21_RS04080 (IPU21_04095) 906545..906715 + 171 WP_014613378.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
IPU21_RS04085 (IPU21_04100) 906716..907069 + 354 WP_014613379.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
IPU21_RS04090 (IPU21_04105) 907127..908131 + 1005 WP_019165832.1 PP2C family protein-serine/threonine phosphatase -
IPU21_RS04095 (IPU21_04110) 908210..908536 + 327 WP_014613381.1 anti-sigma factor antagonist -
IPU21_RS04100 (IPU21_04115) 908536..909015 + 480 WP_026067010.1 anti-sigma B factor RsbW -
IPU21_RS04105 (IPU21_04120) 908990..909760 + 771 WP_019165834.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-108)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13130.36 Da        Isoelectric Point: 10.4439

>T178026 WP_014613379.1 NZ_CP063368:906716-907069 [Staphylococcus delphini]
MKRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKNKYKLDKDSVILLEQIRT
VDKKRLKEKLTFLSEKKMKEVNNAIGISLGLHMNHHK

Download         Length: 354 bp

>T178026 NZ_CP083819:120575-120760 [Enterobacter roggenkampii]
GTGAAAAGTGCGGATGTCATTACTGTTCTGATCAGCCATGGCTGGAAATGTGTCAGAACGAAAGGAAGCCATCATCAGTT
TCGCCATCCCGAACAGAAAGGGCTGGTTACTGTCCCACATCCCAAGAAGGATATTAAACCGGGCACTCTCGCCCAGATCT
GGCGACAGGCGGGTATTAAACACTGA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6396.04 Da        Isoelectric Point: 3.9930

>AT178026 WP_014613378.1 NZ_CP063368:906545-906715 [Staphylococcus delphini]
MSAFNQTRFKNLEQSLKEGYVQMADLNLSLATEAYPVECEACDCNESHLTTDYKED

Download         Length: 171 bp

>AT178026 NZ_CP083819:120775-121182 [Enterobacter roggenkampii]
ATGTTTTATCCGGCTTACATTCATTCTGACTCCGACGGTAGCGCCAGCGGCTTTTTCCCTGACGTTCCAGGCTGTTTTTT
TGCAGGTGATTCCCTGGACGACGCTTTTCAGGATGCGCGTGATGCGCTCACAGCACACTTCGAAGCGCTATTTGAAATGG
ATAATGCACTGCCTCTTCCGGGTAATGTGGAAGCGCATCTGGAAAGTCGTCCTGAGGATTTCACTGGCGGGCAATGGCTG
TTGGTAGATATTAATATGAAACAGTTCGACGGTAGGGCCGAGCGTATCAACATCACGATGCCTCGACGTTTGCTGGTAAA
AATTGATTCCTTTGTCAGCGAGCATCCTCAGTTCGGTAATCGAAGCGCATTTCTGGCTGAGGCAGCACGTCGCGTGCTGC
CTGGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A4EDC7

Antitoxin

Source ID Structure
AlphaFold DB A0A166MM16

References