Detailed information of TA system TA178025

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsdAT/-
• Location: 891634..892155
• Replicon: chromosome
• Accession: NZ_CP063368
• Organism: Staphylococcus delphini strain 245-1

Toxin (Protein)

• Gene name: TsdT
• Uniprot ID: -
• Locus tag: IPU21_RS04010
• Protein ID: WP_096543014.1
• Coordinates: 891934..892155 (+)
• Length: 74 a.a.

Antitoxin (Protein)

• Gene name: TsdA
• Uniprot ID: A0A2A4GP16
• Locus tag: IPU21_RS04005
• Protein ID: WP_019165818.1
• Coordinates: 891634..891921 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IPU21_RS03980 (IPU21_03995)	886894..887697	+	804	WP_096665741.1	hydroxyethylthiazole kinase	-
IPU21_RS03985 (IPU21_04000)	887687..888325	+	639	WP_212575265.1	thiamine phosphate synthase	-
IPU21_RS03990 (IPU21_04005)	888414..889280	+	867	WP_096543018.1	membrane protein insertase YidC	-
IPU21_RS03995 (IPU21_04010)	889335..889991	-	657	WP_212575266.1	HD domain-containing protein	-
IPU21_RS04000 (IPU21_04015)	890012..891502	-	1491	WP_212575267.1	cardiolipin synthase	-
IPU21_RS04005 (IPU21_04020)	891634..891921	+	288	WP_019165818.1	copper-sensing transcriptional repressor CsoR	Antitoxin
IPU21_RS04010 (IPU21_04025)	891934..892155	+	222	WP_096543014.1	heavy metal-associated domain-containing protein	Toxin
IPU21_RS04015 (IPU21_04030)	892159..892365	+	207	WP_212575268.1	cation transporter	-
IPU21_RS04020 (IPU21_04035)	892466..894646	+	2181	WP_212575850.1	heavy metal translocating P-type ATPase	-
IPU21_RS04025 (IPU21_04040)	894732..894878	+	147	WP_014613367.1	Lmo0850 family protein	-
IPU21_RS04030 (IPU21_04045)	895806..896567	+	762	WP_212575270.1	peptidase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Heavy metal-associated domain, HMA (21-64)

Antitoxin

• Metal-sensitive transcriptional repressor (3-93)

Sequences

Toxin

Protein

• Length: 74 a.a.
• Molecular weight: 8107.18 Da
• Isoelectric Point: 4.3480

>T178025 WP_096543014.1 NZ_CP063368:891934-892155 [Staphylococcus delphini]
MENGYVKVTQLTTEAQQQQLSDRLLRLIGVESVVIDLATQSLTLTYDTPANLNTIEKEIYDAGFPVIQSHKGV

Nucleotide

• Length: 222 bp

>T178025 NZ_CP083815:c4504164-4503793 [Enterobacter asburiae]
ATGGAGCACATGGCGGTGTTCGATACCAATATACTCATCGATCTTTTTAATAATCGCGTTGAGGCTGCGGATGCAATTGA
TCGCACAGCTTCGCATCGAGCCATTAGTCTGATCACATGGATGGAAGTCATGGTGGGGGCCCGCAAACATGGTCACGAAG
CGAAAACTGCGACAGTGATGGGCGTATTTGAGATTATTGATATCACCCGAGATATCGCTGAAAGAAGTGTAATTCTGCGC
GAGAAGCATGGAATGAGACTGCCTGATGCTATCATTCTGGCCACAGCTCAGAGCAGAAATTGTCCGTTGATTTCTCGAAA
CACGAAAGACTTTTCGGGCATTACTGGAGTCGTTTCACCTTACCAGCTGTAG

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 11000.61 Da
• Isoelectric Point: 6.7507

>AT178025 WP_019165818.1 NZ_CP063368:891634-891921 [Staphylococcus delphini]
MTEQAHHSEEIKRNLKSRLNRIEGQVKAINRMIDEDVYCDDVLTQIRATRSALNSVASRLLDHHMKGCIMHKIDAGHQDE
AMEELLVTFQKLMKD

Nucleotide

• Length: 288 bp

>AT178025 NZ_CP083815:c4504409-4504167 [Enterobacter asburiae]
ATGATTCTTTCCGCGGATCTTGATATGGGCAGAATTCTGATCGATTTGTCTGATGACGTAATTCAACGACTGGATAATCT
GAAGCAGCTGCGTAACCGGCCTCGTGCCGAATTGCTTCGGGAAGCCATTGAGCAATATCTCGACCAGCAGAGTTCATCGG
TTATCCGCGATGCGCTTGGCTTGTGGGGAAACCAGCAGGAAGATGGGCTTGAGTATGAACGCAAGCTGCGTGAGGAGTGG
TAA

Structures

Antitoxin

• AlphaFold DB: A0A2A4GP16