Detailed information of TA system TA178024

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): zeta-pezT/zeta-couple_hipB
• Location: 591775..593025
• Replicon: chromosome
• Accession: NZ_CP063368
• Organism: Staphylococcus delphini strain 245-1

Toxin (Protein)

• Gene name: zeta
• Uniprot ID: -
• Locus tag: IPU21_RS02495
• Protein ID: WP_212575847.1
• Coordinates: 592252..593025 (+)
• Length: 258 a.a.

Antitoxin (Protein)

• Gene name: pezT
• Uniprot ID: -
• Locus tag: IPU21_RS02490
• Protein ID: WP_096543209.1
• Coordinates: 591775..592251 (+)
• Length: 159 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IPU21_RS02465 (IPU21_02475)	587320..587895	+	576	WP_212575145.1	nitrate reductase molybdenum cofactor assembly chaperone	-
IPU21_RS02470 (IPU21_02480)	587888..588565	+	678	WP_212575146.1	respiratory nitrate reductase subunit gamma	-
IPU21_RS02475 (IPU21_02485)	588581..589042	+	462	WP_096543211.1	nitrate respiration regulation accessory nitrate sensor NreA	-
IPU21_RS02480 (IPU21_02490)	589043..590077	+	1035	WP_096543210.1	sensor histidine kinase	-
IPU21_RS02485 (IPU21_02495)	590096..590746	+	651	WP_019167019.1	nitrate respiration regulation response regulator NreC	-
IPU21_RS02490 (IPU21_02500)	591775..592251	+	477	WP_096543209.1	helix-turn-helix domain-containing protein	Antitoxin
IPU21_RS02495 (IPU21_02505)	592252..593025	+	774	WP_212575847.1	zeta toxin family protein	Toxin
IPU21_RS02500 (IPU21_02510)	593179..593511	-	333	WP_212575148.1	hypothetical protein	-
IPU21_RS02505 (IPU21_02515)	593835..594998	+	1164	WP_212575149.1	nitrate/nitrite transporter	-
IPU21_RS02510 (IPU21_02520)	595128..596723	-	1596	WP_212575150.1	M20 family metallopeptidase	-
IPU21_RS02515 (IPU21_02525)	596907..597263	+	357	WP_096543203.1	DUF3139 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (28-213)

Antitoxin

• Cro/C1-type helix-turn-helix domain (3-60)

Sequences

Toxin

Protein

• Length: 258 a.a.
• Molecular weight: 29926.56 Da
• Isoelectric Point: 9.6457

>T178024 WP_212575847.1 NZ_CP063368:592252-593025 [Staphylococcus delphini]
MGLIEYTKIDFQTALERNYRGLTRGKTPIKRPIAILLGGQSGAGKTTIHRIKQSHYNGNIIIIDGDTFRLQHPKFIDIQK
EYGKKSVEYTNEFAGRMVESLIELLSEQHYHLLIEGTLRTVDVPRRTAVSLKSKGYQVELSLIATKPYLSYLSTLLRYEQ
NYSISPKYARATPKKYHDNIVGNLVENLNILEKEKIFDRIQIFKRDKSCVYDSYKNGELMASEKLHELLYGVWDLKEKEM
LEYCENELKILREAKRK

Nucleotide

• Length: 774 bp

>T178024 NZ_CP083815:c3671240-3670830 [Enterobacter asburiae]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCGCAGTGGATGTCTTTATTGCTCCACGGCCTGGTTGCGGC
CTTTGTTTTGCTGATGCCGTGGCCGCTGAGCTATACGCCGCTGTGGCTGCTGTTACTGTCGTTTGTCGTTTTTGACAGCG
TACGCAGCCAGCGTCGCATTAATGCCCGTCAGGGAGAGATTAAATTACTGATGGATTCCCGCCTGCGCTGGCAGGGTAAA
GAGTGGGATATTCTCGGTATGCCCTGGATGCTCAACTGCGGCATGATGTTACGGTTACGCAAGGTGGACGGCGGGCGTTG
CCAGCATCTGTGGCTGGCGGCTGACAGTATGGATGCTGCCGAGTGGCGAGACCTGCGCCGGATGCTGTTGCAACAGACGA
CGCAGGGGTAA

Antitoxin

Protein

• Length: 159 a.a.
• Molecular weight: 17947.45 Da
• Isoelectric Point: 4.5010

>AT178024 WP_096543209.1 NZ_CP063368:591775-592251 [Staphylococcus delphini]
MIGQNIKSLRQSKALTQPEFANMIGISRNSLSRYENGTSSITIGLIDRICEKFDVSYLDIVGKDKLLTPLEEYQLSFKIE
TTKERGASLLAELFDFQNKQGITTDDDTNPWILMSDDLSELINTKIYLVENFNTLERYIGYIDGIEHMLEVAKGRVVA

Nucleotide

• Length: 477 bp

>AT178024 NZ_CP083815:c3671487-3671221 [Enterobacter asburiae]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATTTCCATCATGCCTTT
CTTCCAATATGAGTATGACAGCTTAAGCGATGATGATAAGCGTCTGTTTGTTCGCCTGCTTGAGTCTGACGATCCGGATT
TATTCAACTGGCTGATGAACCACGGCAAACCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA