178023

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF-MazE
Location 2410223..2410827 Replicon chromosome
Accession NZ_CP063367
Organism Staphylococcus delphini strain 2794-1

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag IPU22_RS11365 Protein ID WP_212574782.1
Coordinates 2410489..2410827 (+) Length 113 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag IPU22_RS11360 Protein ID WP_096540352.1
Coordinates 2410223..2410492 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IPU22_RS11335 (IPU22_11330) 2405555..2406160 - 606 WP_212574781.1 DUF2812 domain-containing protein -
IPU22_RS11340 (IPU22_11335) 2406144..2406476 - 333 WP_096540346.1 PadR family transcriptional regulator -
IPU22_RS11345 (IPU22_11340) 2406631..2408172 - 1542 WP_019166288.1 SLC13 family permease -
IPU22_RS11350 (IPU22_11345) 2408753..2409214 - 462 WP_019166289.1 threonine/serine exporter family protein -
IPU22_RS11355 (IPU22_11350) 2409227..2409982 - 756 WP_051005999.1 threonine/serine exporter family protein -
IPU22_RS11360 (IPU22_11355) 2410223..2410492 + 270 WP_096540352.1 AbrB family transcriptional regulator Antitoxin
IPU22_RS11365 (IPU22_11360) 2410489..2410827 + 339 WP_212574782.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
IPU22_RS11370 (IPU22_11365) 2411033..2411788 - 756 WP_212574783.1 heme-dependent peroxidase -
IPU22_RS11375 (IPU22_11370) 2411956..2412945 + 990 WP_212574784.1 phosphate acetyltransferase -
IPU22_RS11380 (IPU22_11375) 2412945..2413781 + 837 WP_212574785.1 lipoate--protein ligase family protein -
IPU22_RS11385 (IPU22_11380) 2414475..2414879 - 405 WP_212574786.1 arsenate reductase (thioredoxin) -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-106)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 13132.26 Da        Isoelectric Point: 9.9095

>T178023 WP_212574782.1 NZ_CP063367:2410489-2410827 [Staphylococcus delphini]
MSIKQFDIIYIDLNPTRGREKQNMRPFLVINNQMMIDGTEFVWVVPITNRELRYPTDIELKTKKGLVSGVIDTIQIRALD
LNARQHHYKDALQDNLKSKVLKAIQTYLNPNY

Download         Length: 339 bp

>T178023 NZ_CP083815:3453736-3454065 [Enterobacter asburiae]
ATGCAAATCATATCATCAGCCCCTACACGGGCGGCTCCGCTCAGCCTGTCACCCGTTGAAATCTGGCAGCGGCTGCTAAC
TCATCTGTTATCGCAGCACTATGGCCTGACGCTGAATGACACACCGTTCAGTTATGAAACCACCATACGGGAACATATTG
ATGCAGGAGTATCGCTCAGCGATGCGGTGAACTTTCTGGTAGAAAAATACGGGCTTGTCCGTATCGACCGGAAAGGATTT
TCATGGCAAGAACAGACCCCGTATATTTCCGTAGTAGATATTCTGATGGCAAGGCGCTCGACCGGCCTGCTAAAAACTAC
CGTGAAATAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9976.15 Da        Isoelectric Point: 4.4501

>AT178023 WP_096540352.1 NZ_CP063367:2410223-2410492 [Staphylococcus delphini]
MTQTFNDVSISTERIFKNGNSQAMSLSKKMIQSVDFEIGDTVEVQKINGGLFITKKEVSIEDSIKNFFQNGGKYQESEVD
FGESVGREI

Download         Length: 270 bp

>AT178023 NZ_CP083815:3453332-3453697 [Enterobacter asburiae]
ATGAACAATCACTCAGAATCCGGCACCAGGCCGGAGAATTCCGCCATCCAGCAATGGGGACTGAAGCGCGCTATAACACC
GTGTTTTGGCGCACGACTGGTTCAGGAGGGCAACCGTCTGCACTATCTGGCTGACCGCGCAGGATTTAGCGGGGCGTTCA
CCGACGATGTTGCAATGCACCTCGACCAGGCATTTCCGCTCATGATGAAGCAACTTGAGCTGATGCTGACCAGTGGAGAG
CTCAACCCTAGCCACCCGCACTGCGTCACGCTTTACCATAACGGGCTCACCTGCGAAGCCGACACACTCGGCTCCTGTGG
CTATGTCTACATTGCTATCTATCCTGAGCAGACTGAGCCGCAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References