Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 906552..907076 Replicon chromosome
Accession NZ_CP063367
Organism Staphylococcus delphini strain 2794-1

Toxin (Protein)


Gene name mazF Uniprot ID A0A2A4EDC7
Locus tag IPU22_RS04085 Protein ID WP_014613379.1
Coordinates 906723..907076 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A166MM16
Locus tag IPU22_RS04080 Protein ID WP_014613378.1
Coordinates 906552..906722 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IPU22_RS04055 (IPU22_04055) 902463..902936 + 474 WP_212575274.1 PH domain-containing protein -
IPU22_RS04060 (IPU22_04060) 902929..904440 + 1512 WP_096606401.1 PH domain-containing protein -
IPU22_RS04065 (IPU22_04065) 904424..904939 + 516 WP_096606399.1 PH domain-containing protein -
IPU22_RS04070 (IPU22_04070) 904936..905286 + 351 WP_212575275.1 holo-ACP synthase -
IPU22_RS04075 (IPU22_04075) 905320..906468 + 1149 WP_212575276.1 alanine racemase -
IPU22_RS04080 (IPU22_04080) 906552..906722 + 171 WP_014613378.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
IPU22_RS04085 (IPU22_04085) 906723..907076 + 354 WP_014613379.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
IPU22_RS04090 (IPU22_04090) 907134..908138 + 1005 WP_019165832.1 PP2C family protein-serine/threonine phosphatase -
IPU22_RS04095 (IPU22_04095) 908217..908543 + 327 WP_014613381.1 anti-sigma factor antagonist -
IPU22_RS04100 (IPU22_04100) 908543..909022 + 480 WP_026067010.1 anti-sigma B factor RsbW -
IPU22_RS04105 (IPU22_04105) 908997..909767 + 771 WP_019165834.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-108)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13130.36 Da        Isoelectric Point: 10.4439

>T178022 WP_014613379.1 NZ_CP063367:906723-907076 [Staphylococcus delphini]
MKRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKNKYKLDKDSVILLEQIRT
VDKKRLKEKLTFLSEKKMKEVNNAIGISLGLHMNHHK

Download         Length: 354 bp

>T178022 NZ_CP083815:c2846856-2846503 [Enterobacter asburiae]
GTGTGGGCAATTAACACGACAGACAGGTTTGATCGCTGGTTCACTTCGCTTGACGATACCGAACGCGCCAGCGTACTTGC
AGCACTGCTGGTTTTGCGAGAGAAGGGGCAGGGTTTAGCGAGACCCTACGCTGATACGCTTAAAAGCTCTCGTCACAGCA
ACATGAAAGAGCTACGTATTCAGAGTAAGGGCGATCCCTTGCGGGCGTTTTTCGCCTTTGATCCAAACCGAATGGGTATC
GTGCTTTGTGCGGGTAATAAGGTCGGCAATGAAAGGCGATTCTACGATGAGATGCTTCTCGTTGCTGACCGGGAATTCAC
TCACTGGCTGAATACATTAAAAGAGAGGGAATAG

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6396.04 Da        Isoelectric Point: 3.9930

>AT178022 WP_014613378.1 NZ_CP063367:906552-906722 [Staphylococcus delphini]
MSAFNQTRFKNLEQSLKEGYVQMADLNLSLATEAYPVECEACDCNESHLTTDYKED

Download         Length: 171 bp

>AT178022 NZ_CP083815:c2846498-2846196 [Enterobacter asburiae]
ATGGGAAGAACCCTTGAGCAGCTTATAGCGGATGAAAAGCCGGAGGTTGTCGCCAGCGCTCAGGCGATAGCAACGGATAT
TTTGCTCAACATTCATCTTGCTGAGTTACGCGAGAAAGTACAAAAAACGCAGGTAGAAATGGCGCAGGCGTTAGGTATCA
GGCAACCTACCGTTGCGGTAATGGAAAAGCCCGGGCGCGATTTGAAACTCTCTTCTCTCAAGCGCTACGTTGAGGCGGCG
GGCGGAAAGCTGCGGCTTGATGTGGAGCTGCCGGATGGCTCGCACTATGAGTTTGTGCTGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A4EDC7

Antitoxin

Source ID Structure
AlphaFold DB A0A166MM16

References