Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 891641..892162 Replicon chromosome
Accession NZ_CP063367
Organism Staphylococcus delphini strain 2794-1

Toxin (Protein)


Gene name TsdT Uniprot ID -
Locus tag IPU22_RS04010 Protein ID WP_096543014.1
Coordinates 891941..892162 (+) Length 74 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A2A4GP16
Locus tag IPU22_RS04005 Protein ID WP_019165818.1
Coordinates 891641..891928 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IPU22_RS03980 (IPU22_03980) 886901..887704 + 804 WP_096665741.1 hydroxyethylthiazole kinase -
IPU22_RS03985 (IPU22_03985) 887694..888332 + 639 WP_212575265.1 thiamine phosphate synthase -
IPU22_RS03990 (IPU22_03990) 888421..889287 + 867 WP_096543018.1 membrane protein insertase YidC -
IPU22_RS03995 (IPU22_03995) 889342..889998 - 657 WP_212575266.1 HD domain-containing protein -
IPU22_RS04000 (IPU22_04000) 890019..891509 - 1491 WP_212575267.1 cardiolipin synthase -
IPU22_RS04005 (IPU22_04005) 891641..891928 + 288 WP_019165818.1 copper-sensing transcriptional repressor CsoR Antitoxin
IPU22_RS04010 (IPU22_04010) 891941..892162 + 222 WP_096543014.1 heavy metal-associated domain-containing protein Toxin
IPU22_RS04015 (IPU22_04015) 892166..892372 + 207 WP_212575268.1 cation transporter -
IPU22_RS04020 (IPU22_04020) 892473..894653 + 2181 WP_212575269.1 heavy metal translocating P-type ATPase -
IPU22_RS04025 (IPU22_04025) 894739..894885 + 147 WP_014613367.1 Lmo0850 family protein -
IPU22_RS04030 (IPU22_04030) 895813..896574 + 762 WP_212575270.1 peptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(21-64)

Antitoxin

Metal-sensitive transcriptional repressor

(3-93)


Sequences

Toxin        


Download         Length: 74 a.a.        Molecular weight: 8107.18 Da        Isoelectric Point: 4.3480

>T178021 WP_096543014.1 NZ_CP063367:891941-892162 [Staphylococcus delphini]
MENGYVKVTQLTTEAQQQQLSDRLLRLIGVESVVIDLATQSLTLTYDTPANLNTIEKEIYDAGFPVIQSHKGV

Download         Length: 222 bp

>T178021 NZ_CP083815:c2656555-2656452 [Enterobacter asburiae]
GGCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATAGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 11000.61 Da        Isoelectric Point: 6.7507

>AT178021 WP_019165818.1 NZ_CP063367:891641-891928 [Staphylococcus delphini]
MTEQAHHSEEIKRNLKSRLNRIEGQVKAINRMIDEDVYCDDVLTQIRATRSALNSVASRLLDHHMKGCIMHKIDAGHQDE
AMEELLVTFQKLMKD

Download         Length: 288 bp

>AT178021 NZ_CP083815:2656446-2656590 [Enterobacter asburiae]
ACAGATAAAAAGAGACCGAATACTATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGT
TGGCATTAATGCAGGCTAAGTCGCCTTGCCTTTTAAGAATAGATGACGACGCCAGGTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2A4GP16

References