Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 6262749..6263556 Replicon chromosome
Accession NZ_CP063362
Organism Xanthobacter sp. YN2

Toxin (Protein)


Gene name TacT3 Uniprot ID -
Locus tag EZH22_RS29365 Protein ID WP_203193799.1
Coordinates 6262749..6263273 (-) Length 175 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID -
Locus tag EZH22_RS29370 Protein ID WP_203196834.1
Coordinates 6263266..6263556 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EZH22_RS29345 6259607..6260086 - 480 WP_203193796.1 hypothetical protein -
EZH22_RS29350 6260956..6261282 - 327 WP_203193797.1 tyrosine-type recombinase/integrase -
EZH22_RS29355 6261260..6261520 - 261 WP_203193798.1 phage integrase N-terminal SAM-like domain-containing protein -
EZH22_RS29360 6261671..6262726 - 1056 Protein_5813 recombinase family protein -
EZH22_RS29365 6262749..6263273 - 525 WP_203193799.1 GNAT family N-acetyltransferase Toxin
EZH22_RS29370 6263266..6263556 - 291 WP_203196834.1 DUF1778 domain-containing protein Antitoxin
EZH22_RS29375 6263748..6264365 + 618 Protein_5816 recombinase family protein -
EZH22_RS29380 6264712..6265095 + 384 WP_132036247.1 transposase -
EZH22_RS29385 6265092..6265433 + 342 WP_132036245.1 IS66 family insertion sequence element accessory protein TnpB -
EZH22_RS29390 6265510..6267165 + 1656 WP_203192850.1 IS66 family transposase -
EZH22_RS29395 6267328..6268044 - 717 WP_203193800.1 GGDEF domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 6260956..6267165 6209


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(11-87)


Sequences

Toxin        


Download         Length: 175 a.a.        Molecular weight: 18597.28 Da        Isoelectric Point: 8.8227

>T178019 WP_203193799.1 NZ_CP063362:c6263273-6262749 [Xanthobacter sp. YN2]
VLDWREEPIGRHHDRKAFDCGTSELNEYLRRHARQNHEGGGSKTFVAVAPSAPETIFGYYSISPASIAFSKVPAPLTKGL
GRYEVAVYRLARLAVALPQQGQGLGGDLLLAAGARALAVAAQVGGVALAIDAKDEKAARWYKRFGAMPLLDSSPLSLILP
FKTIIDALDAAQGE

Download         Length: 525 bp

>T178019 NZ_CP083815:c1026981-1026763 [Enterobacter asburiae]
ATGTCTGATAAACCACTCACAAAAATCGATTATTTGATGCGCTTACGACGTTGTCAGTCAATTGACACGCTTGAGCGCGT
CATTGAAAAGAATAAATACGAGCTTTCTGATAATGAACTGGCGGTATTTTATTCAGCCGCTGACCATCGTCTTGCTGAAC
TGACAATGAATAAACTGTATGACAAAATCCCTACTTCTGTGTGGAAATTTGTCCGTTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10573.06 Da        Isoelectric Point: 11.1401

>AT178019 WP_203196834.1 NZ_CP063362:c6263556-6263266 [Xanthobacter sp. YN2]
MAQTQSSRDDRIELRTTRDEKRLLTAAAAHERLDLTSFIMRAALPAARDVVENAERISLSERDSLRVLDLLENPPAPTPA
LLAAARRRIARGGKGA

Download         Length: 291 bp

>AT178019 NZ_CP083815:c1027383-1027009 [Enterobacter asburiae]
ATGGACGAGTACTCGCCAAAAAGGCATGATATCGCGCAGTTGAAATTTCTCTGCGAATCCTTGTACCATGACTGCCTTGC
CAATCTTGATGAAAGTAACCATGGCTGGGTAAACGACCCAACATCTGCCATCAATTTACAGTTGAATGAGCTGATAGAGC
ATATCGCAACCTTCGCACTTAATTATAAAATTAAGTACAATGAAGATAATAAGCTCATTGAGCAAATTGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGTTACGGCATTAACGCGCAGGATTTGCAAAAATGGCGTAAAACGGGAAATCGGCT
ATTCCGCTGTTTCGTCAACGTGAGCAGAGCTAACCCGGTGAGTCTTTCCTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References