Detailed information of TA system TA178018

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 6228372..6228957
• Replicon: chromosome
• Accession: NZ_CP063362
• Organism: Xanthobacter sp. YN2

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: EZH22_RS29165
• Protein ID: WP_203193771.1
• Coordinates: 6228658..6228957 (+)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: EZH22_RS29160
• Protein ID: WP_203193770.1
• Coordinates: 6228372..6228671 (+)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EZH22_RS29145	6225802..6226035	+	234	WP_203193767.1	TraC family protein	-
EZH22_RS29150	6226085..6226324	+	240	WP_203193768.1	conjugal transfer protein TraD	-
EZH22_RS29155	6226321..6228228	+	1908	WP_203193769.1	Ti-type conjugative transfer system protein TraG	-
EZH22_RS29160	6228372..6228671	+	300	WP_203193770.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
EZH22_RS29165	6228658..6228957	+	300	WP_203193771.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
EZH22_RS29170	6229130..6229318	-	189	WP_203196827.1	hypothetical protein	-
EZH22_RS29175	6229747..6230088	-	342	WP_203196843.1	hypothetical protein	-
EZH22_RS29180	6230429..6230914	+	486	WP_203193772.1	DUF2384 domain-containing protein	-
EZH22_RS29185	6230911..6231414	+	504	WP_203193773.1	RES domain-containing protein	-
EZH22_RS29190	6231609..6232802	+	1194	WP_203193774.1	DUF1173 domain-containing protein	-
EZH22_RS29195	6232891..6233154	+	264	WP_203196828.1	WGR domain-containing protein	-
EZH22_RS29200	6233138..6233437	-	300	WP_203196829.1	hypothetical protein	-
EZH22_RS29205	6233546..6233815	-	270	WP_203193775.1	type II toxin-antitoxin system prevent-host-death family antitoxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	5938432..6250456	312024

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-90)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (4-58)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11457.90 Da
• Isoelectric Point: 4.9246

>T178018 WP_203193771.1 NZ_CP063362:6228658-6228957 [Xanthobacter sp. YN2]
VRRLEWREDARADLLAIVDFISDDNPDASQRLKDDIEAKTSKLPEHPRLYRPGRVDGTREMVVRSNYLIVYAENAHAISI
LRVLHAAQQWPPVPEDEEI

Nucleotide

• Length: 300 bp

>T178018 NZ_CP083815:564901-565188 [Enterobacter asburiae]
ATGCCAACGGAGTTTGAATGGGATACCAACAAAGCGAAAAGCAATCTCATTAAGCATGGGATCCGCTTTGAAGAAGCTGT
TCTGGTGTTTGACGATCCTTACCATTTATCTTTGCAGGATCGTCATGAAAATGGAGAGTTCCGTTGGCAGACCATTGGCC
TTGTACATGGTCTAATTGTCATTATGGTCGCACACACGGTACGTTTTGAAAGTGGTGACGAAGTCATTCGAATCATTAGC
GCACGAAAGGCGGACCGTAAAGAGAGGAGCCGTTATGAGCATGGTTAA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 10990.62 Da
• Isoelectric Point: 10.0074

>AT178018 WP_203193770.1 NZ_CP063362:6228372-6228671 [Xanthobacter sp. YN2]
MAAQTSMLHIRVDDKLKADATEKLASFGLTVSDAVRILLTRVVKEGALPAGLTTDPEAHDAWFRAKVREALDDTRPSVPH
RQVMDETQALIDRKRRAKA

Nucleotide

• Length: 300 bp

>AT178018 NZ_CP083815:565175-565477 [Enterobacter asburiae]
ATGAGCATGGTTAAACATAAACGCGGTAGTGCGCCTGAGATGAGTGCTCGCCGTGAGGCTGAGCTCAAAGCACTAGCCGA
AAAATCGGAAGCAGAGATTGATTACAGCGATATCCCTGCCACGGGAGATGAACAGTGGTCAGGGGCGGTGCGAGGGAAGT
TCTATCGGCCACTCAAAACTCAGGCGTCTGTACGTATCGACGCTGACGTGATGGAGTGGCTTAAACGGCCTGGAAAAGGT
TACCAGACGAGGCTCAATGCCATTTTGCGTGAAGCTATGCTGCGCGATCAAAACAAAAAATAA