Detailed information of TA system TA178017

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC(toxin)
• Location: 6057730..6058370
• Replicon: chromosome
• Accession: NZ_CP063362
• Organism: Xanthobacter sp. YN2

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: EZH22_RS28300
• Protein ID: WP_203193642.1
• Coordinates: 6057987..6058370 (+)
• Length: 128 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A974PN90
• Locus tag: EZH22_RS28295
• Protein ID: WP_011992919.1
• Coordinates: 6057730..6057987 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EZH22_RS28260	6053206..6053364	+	159	Protein_5593	helix-turn-helix domain-containing protein	-
EZH22_RS28265	6053675..6054106	-	432	WP_203193638.1	type II toxin-antitoxin system VapC family toxin	-
EZH22_RS28270	6054103..6054741	-	639	WP_203193639.1	DUF433 domain-containing protein	-
EZH22_RS28275	6054842..6055682	-	841	Protein_5596	hypothetical protein	-
EZH22_RS28280	6055733..6055864	-	132	WP_203196812.1	VOC family protein	-
EZH22_RS28285	6055898..6056605	-	708	WP_203193640.1	SMC-Scp complex subunit ScpB	-
EZH22_RS28290	6056607..6057560	-	954	WP_203193641.1	DUF1403 family protein	-
EZH22_RS28295	6057730..6057987	+	258	WP_011992919.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
EZH22_RS28300	6057987..6058370	+	384	WP_203193642.1	type II toxin-antitoxin system VapC family toxin	Toxin
EZH22_RS28305	6058594..6059525	+	932	Protein_5602	recombinase family protein	-
EZH22_RS28310	6060389..6060814	-	426	Protein_5603	TniQ family protein	-
EZH22_RS28315	6061125..6061781	-	657	Protein_5604	TniB family NTP-binding protein	-
EZH22_RS28320	6061791..6061949	+	159	Protein_5605	type II toxin-antitoxin system VapC family toxin	-
EZH22_RS28325	6061949..6063033	+	1085	Protein_5606	tyrosine-type recombinase/integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	5938432..6250456	312024

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (1-124)

Antitoxin

• Antitoxin VapB-like (1-84)

Sequences

Toxin

Protein

• Length: 128 a.a.
• Molecular weight: 13853.00 Da
• Isoelectric Point: 4.8780

>T178017 WP_203193642.1 NZ_CP063362:6057987-6058370 [Xanthobacter sp. YN2]
MVIDTSAIVAILRNEPEADALERSIVGAPVRLVPATCVFEARMVLVSRRGEHALAEIDLWLTKIGADIIPVDAELADLAT
QAWLAYGKGRHPAALNFADCFSYALSKRSNERLLFIGNDFSKTDILA

Nucleotide

• Length: 384 bp

>T178017 NZ_CP083815:c522492-522115 [Enterobacter asburiae]
ATGCAAACCCAATCTATACACCCTGTACGGGCGACGGCGTCACGCCCATCTCCTGTCGATATCTGGCAAACCCTGTTGAC
GTACCTCCTGGAGCAACATTACGGGCTCACACTTAACGACACCCCGTTTGGCAACGACATGGTGATCCAGGAGCATATTG
AGGCTGGTATCTCACTGTGCGATGGCGTCAATTTTATCGTCGAAAAGTACGAACTGGTCCGTATCGATCGCCACGGTTTC
AGCACAGAAACACAGTCACCGCTTATTGGCAGCATCGATATCCTTCGTGCACGAAAAGCGACCGGGCTGATGACCCGCAA
CGATTACAAAGTGGTCACCGACATCACCACCGGCAAATACAGCGGGGGGACACGATGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9431.68 Da
• Isoelectric Point: 6.7263

>AT178017 WP_011992919.1 NZ_CP063362:6057730-6057987 [Xanthobacter sp. YN2]
MSLNIKNPATVALADELARRQGVTKTAAIHQALSERLHRMGYGDTAQARLLGELRAIRERVARLPELDTRSDEEIVGFDE
HGIPN

Nucleotide

• Length: 258 bp

>AT178017 NZ_CP083815:c522929-522555 [Enterobacter asburiae]
ATGTCCGATACTGAAAGTACCGATGTCGGGGCGATACCTCAGCACACAATCGCTTCCCCTTGGTGGGGGCTGAAGTGCGA
CACCACACCCTGTTTTGGTACCCGCCTGGTCCAGGAGGGCAATCAGCTACACTTCCTGTCTGACCGGAGCAATTTCACCG
GAACATTTCACGAAAGCGAAGCATTGCAGCTTAATCAGGCTTTTCCCCTGATGCTCAAACAGCTTGAGTTGATGTTGGTA
TCCGGTGAGCTCAACCCACGCCACCAGCACTGCGTCACGTTGTATCACAATGGTCTCATCTGCGAAGCGGACACACTGGG
CAGTTGTGGTTATATCTACCTCGCGATTTATCCGGGGGAACCGCCAGCAGCGTAA