Detailed information of TA system TA178016

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): rlegTA/AbiEii-AbiEi
• Location: 4836175..4837705
• Replicon: chromosome
• Accession: NZ_CP063362
• Organism: Xanthobacter sp. YN2

Toxin (Protein)

• Gene name: rlegT
• Uniprot ID: -
• Locus tag: EZH22_RS22640
• Protein ID: WP_203192666.1
• Coordinates: 4836785..4837705 (+)
• Length: 307 a.a.

Antitoxin (Protein)

• Gene name: rlegA
• Uniprot ID: -
• Locus tag: EZH22_RS22635
• Protein ID: WP_203192665.1
• Coordinates: 4836175..4836795 (+)
• Length: 207 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EZH22_RS22615	4831848..4832120	+	273	WP_203196712.1	hypothetical protein	-
EZH22_RS22620	4832265..4834397	-	2133	WP_203192662.1	ParB/RepB/Spo0J family partition protein	-
EZH22_RS22625	4834480..4834929	-	450	WP_203192663.1	hypothetical protein	-
EZH22_RS22630	4834929..4835891	-	963	WP_203192664.1	DUF1738 domain-containing protein	-
EZH22_RS22635	4836175..4836795	+	621	WP_203192665.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
EZH22_RS22640	4836785..4837705	+	921	WP_203192666.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
EZH22_RS22645	4837782..4839086	+	1305	WP_203196714.1	SIR2 family protein	-
EZH22_RS22650	4839094..4841202	+	2109	WP_203192667.1	DUF87 domain-containing protein	-
EZH22_RS22655	4841202..4842434	+	1233	WP_203192668.1	exonuclease SbcCD subunit D	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (38-260)

Antitoxin

• Transcriptional regulator, AbiEi antitoxin (14-56)

Sequences

Toxin

Protein

• Length: 307 a.a.
• Molecular weight: 33837.80 Da
• Isoelectric Point: 4.8757

>T178016 WP_203192666.1 NZ_CP063362:4836785-4837705 [Xanthobacter sp. YN2]
MPREPRNIGASVRARLLDRARAERSDFQILLTRYALERLLYRLSVSPHRDRFILKGAMLFVTWVADPFRPTRDLDLLGHG
DNDAEAIAETFRAICAQPVADDGVTFDVAALMAAPIREEVEYGGVRVRTTATIAGARISIQVDIGFGDAITPAAIEIDYP
ALLDAPAPHLRAYPVETVVAEKFEALVTLGVANSRLKDFYDLWVISRTFELRQAALVEAVQRTFERRGTALPSEIPVGLT
EEFAEAWAAQWRAFLGRDRMVAAPDAFAVTIADLRVFLMPLVVGLNEQRVWPPSGPWSPGAAIDEA

Nucleotide

• Length: 921 bp

>T178016 NZ_CP083815:c251778-251476 [Enterobacter asburiae]
ATGAAGGAGATCGTTCAGACAGAATCCTTCCAACGCTGGGAGCAAAACTTAAAAGATCGGCGAGCGAAAACCATTATCGC
TTCCCGCCTCTTTCGGTTGGCAAATGGTTTAGCGGGCGACATTAAACCCGTGGGCGAAGGTATAAGTGAGCTGAGGATCC
ACTATGGTCCGGGCTACAGAATCTATTTTAAAGACCAGGGCAATTGCATCATCGTGCTGTTGTGTGGTGGTGACAAAAGC
AGCCAGGCCAGAGACATACTTATGGCAAAAATGCTGAGCAATCCCAATGGCAGGAGTGAATGA

Antitoxin

Protein

• Length: 207 a.a.
• Molecular weight: 23353.36 Da
• Isoelectric Point: 10.4750

>AT178016 WP_203192665.1 NZ_CP063362:4836175-4836795 [Xanthobacter sp. YN2]
MTSTTAQRLRALDLLKARGMLRLKEFVAEGIGPETLARLVREKAVVRPARGLYQLPDTQVEAAHVLAEAAVLVPKGVVCL
TSALQYHELTLQMPSAVWMAIDRAAWRPKIDYPPIRFVRFTGSALTEGVERHRIESVDVPITDPARTIVDCFRYRTKVGL
DVAMEGLREGLRRRRCKPDQLWRYARKARVWSIMRPYVEAMVSDAA

Nucleotide

• Length: 621 bp

>AT178016 NZ_CP083815:c251473-251186 [Enterobacter asburiae]
ATGCATAAATTAACACCCTACGATCCAGCCAATGCGCTGGTGGATGACGAGGAAATCGCCGTGTTTATGGCTGATGCCTT
AGAAACGGGCGATTCAGCGTATATTGCTAAAGCTCTGGGCGTCATCGCGCGAGCGAAAGGAATGTCGACCATTTCACAGC
AAACTGGCCTATCACGAGAGCAACTGTATCGATCGTTCAGTGATAAAGGAAACCCAACGCTTAAAACCACTCTGGCGGTC
ATGAAAGCATTGGGTCTTGGGCTAACAATCAAACACGCTGGAGATTAA